NECAB2 - N-terminal EF-hand calcium binding protein 2 Gene

Also Known as EFCBP2; stip-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54550

About NECAB2

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:83,965,177-84,002,776 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 2 paralogues. Biased expression in brain (RPKM 9.4), kidney (RPKM 3.0) and 3 other tissues.

Summary

The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. [provided by RefSeq, Jul 2016]

NECAB2 Products (3)

mRNA Protein Name
NM_001329748.1 NP_001316677.1 N-terminal EF-hand calcium-binding protein 2 isoform 2
NM_001329749.2 NP_001316678.1 N-terminal EF-hand calcium-binding protein 2 isoform 3
NM_019065.3 NP_061938.2 N-terminal EF-hand calcium-binding protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables A2A adenosine receptor binding IDA
IDA: Inferred from direct assay
17689978 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17689978 GOA
enables type 5 metabotropic glutamate receptor binding IDA
IDA: Inferred from direct assay
19694902 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of G protein-coupled receptor internalization IDA
IDA: Inferred from direct assay
17689978 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19694902 GOA
involved in positive regulation of adenosine receptor signaling pathway IDA
IDA: Inferred from direct assay
17689978 GOA
involved in positive regulation of glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
19694902 GOA
involved in positive regulation of protein localization to membrane IDA
IDA: Inferred from direct assay
19694902 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19694902 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NECAB2 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (65 - 123)

ABM

ABM: Antibiotic biosynthesis monooxygenase (288 - 358)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

N-terminal EF-hand calcium-binding protein 2

  • EF-hand calcium-binding protein 2

NECAB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NECAB2 Q7Z6G3 GRM5 Homo sapiens P41594-1
Pull Down
19694902
Intra
NECAB2 Q7Z6G3 ADORA2A Homo sapiens P29274
Pull Down
17689978
Intra
NECAB2 Q7Z6G3 ADORA2A Homo sapiens P29274
Confocal
17689978
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09171 NECAB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NECAB2 RGD RGD:621844
Felis catus NECAB2 VGNC VGNC:63763
Mus musculus NECAB2 MGD MGI:2152211
Macaca mulatta NECAB2 VGNC VGNC:75239
Bos taurus NECAB2 VGNC VGNC:31978
Others NECAB2 NCBI