CROT - carnitine O-octanoyltransferase Gene

Also Known as COT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54677

About CROT

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:87,345,664-87,399,794 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 12.0), urinary bladder (RPKM 8.5) and 22 other tissues.

Summary

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

CROT Products (3)

mRNA Protein Name
NM_001143935.2 NP_001137407.1 peroxisomal carnitine O-octanoyltransferase isoform 1
NM_001243745.3 NP_001230674.1 peroxisomal carnitine O-octanoyltransferase isoform 3
NM_021151.4 NP_066974.2 peroxisomal carnitine O-octanoyltransferase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carnitine O-octanoyltransferase activity IDA
IDA: Inferred from direct assay
10486279 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in fatty acid beta-oxidation IDA
IDA: Inferred from direct assay
21619872 GOA
involved in fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
21619872 GOA
involved in generation of precursor metabolites and energy IDA
IDA: Inferred from direct assay
10486279 GOA
involved in medium-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
10486279 GOA
Cellular Component GO Annotation Evidence References Source
located in peroxisome IDA
IDA: Inferred from direct assay
21619872 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CROT Protein Structure

Carn_acyltransf

Carn_acyltransf: Choline/Carnitine o-acyltransferase (19 - 604)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 612 a.a.
Protein Preferred Names Protein Names

peroxisomal carnitine O-octanoyltransferase

  • peroxisomal carnitine acyltransferase

Recombinant CROT Proteins

Cat. No. Product Name Accession Purity
HY-P74218 CROT Protein, Human (V474L, sf9, His) Q9UKG9-1 (M1-L612, V474L) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03194 CROT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17367 Crot Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23821 Crot Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CROT VGNC VGNC:27723
Rattus norvegicus CROT RGD RGD:70908
Felis catus CROT VGNC VGNC:61188
Macaca mulatta CROT VGNC VGNC:71495
Mus musculus CROT MGD MGI:1921364
Canis familiaris CROT VGNC VGNC:39627
Others CROT NCBI