Rcan1 - regulator of calcineurin 1 Gene

Also Known as CSP1; DSC1; RCN1; Dscr1; MCIP1; CALP1L; Adapt78

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54720

Summary

Predicted to enable calcium-dependent protein serine/threonine Phosphatase regulator activity and identical protein binding activity. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; response to ischemia; and short-term memory. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of Calcineurin 1). [provided by Alliance of Genome Resources, Apr 2022]

Rcan1 Products (2)

mRNA Protein Name
NM_001081549.2 NP_001075018.1 calcipressin-1 isoform 1
NM_019466.4 NP_062339.2 calcipressin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12809556 MGI
enables protein phosphatase inhibitor activity IDA
IDA: Inferred from direct assay
16024798 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcineurin-NFAT signaling cascade IGI
IGI: Inferred from genetic interaction
16648267 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
16648267 MGI
acts upstream of or within locomotion involved in locomotory behavior IGI
IGI: Inferred from genetic interaction
16648267 MGI
acts upstream of or within response to ischemia IMP
IMP: Inferred from mutant phenotype
16648267 MGI
acts upstream of or within response to oxidative stress IGI
IGI: Inferred from genetic interaction
16648267 MGI
acts upstream of or within response to stress IGI
IGI: Inferred from genetic interaction
16648267 MGI
acts upstream of or within response to stress IMP
IMP: Inferred from mutant phenotype
16648267 MGI
acts upstream of or within short-term memory IGI
IGI: Inferred from genetic interaction
16648267 MGI
acts upstream of or within skeletal muscle fiber development IDA
IDA: Inferred from direct assay
16024798 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10722714 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10722714 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcipressin-1

  • calcineurin inhibitor

  • down syndrome critical region protein 1 homolog

  • myocyte-enriched calcineurin-interacting protein 1

Rcan1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rcan1 Q9JHG6 Fmr1 Mus musculus P35922
FRET
22863780
Intra
Rcan1 Q9JHG6 Dyrk1a Mus musculus Q61214
Anti Bait CoIP
21965663
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11779 RCAN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21728 Rcan1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28245 Rcan1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rcan1 NCBI NCBI:1827