Gsdme - gasdermin E Gene

Also Known as Dfna5; Fin15; Dfna5h; EG14210; 2310037D07Rik; 4932441K13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54722

Summary

Enables cardiolipin binding activity. Involved in cellular response to virus and necrotic cell death. Acts upstream of or within inner ear receptor cell differentiation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E). [provided by Alliance of Genome Resources, Apr 2022]

Gsdme Products (1)

mRNA Protein Name
NM_018769.4 NP_061239.1 gasdermin-E precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cardiolipin binding IDA
IDA: Inferred from direct assay
28459430 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
28045099 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
16023581 MGI
involved in pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
28045099 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28209736 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gasdermin-E

  • deafness associated tumor suppressor

  • deafness, autosomal dominant 5 homolog

  • non-syndromic hearing impairment protein 5 homolog

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0621 Triclabendazole Inhibitor 99.36% Yes

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111770 2-Bromohexadecanoic acid Inhibitor 99.95% Unkown
HY-P10939A Ac-DMLD-CMK TFA Inhibitor 98.44% Unkown
HY-RS05858 GSDME Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16846 Gsdme Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175381 DeFer-2 98.25% Unkown
HY-181005 FGFR-IN-25 / Unkown
HY-B0621S Triclabendazole-d3 / Unkown
HY-N15380 4,4′-Secalonic acid D / Unkown
HY-P10939 Ac-DMLD-CMK Inhibitor / Unkown
HY-RS23287 Gsdme Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsdme NCBI NCBI:1687