QPCTL - glutaminyl-peptide cyclotransferase like Gene

Also Known as gQC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54814

About QPCTL

This gene has 8 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 3.4), prostate (RPKM 3.3) and 25 other tissues.

Summary

Enables glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Acts upstream of or within peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

QPCTL Products (2)

mRNA Protein Name
NM_001163377.2 NP_001156849.1 glutaminyl-peptide cyclotransferase-like protein isoform 2
NM_017659.4 NP_060129.2 glutaminyl-peptide cyclotransferase-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutaminyl-peptide cyclotransferase activity IDA
IDA: Inferred from direct assay
18486145 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
21288892 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA
IDA: Inferred from direct assay
18486145 GOA
involved in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA
IDA: Inferred from direct assay
21288892 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
18486145 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QPCTL Protein Structure

Peptidase_M28

Peptidase_M28: Peptidase family M28 (162 - 365)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

glutaminyl-peptide cyclotransferase-like protein

  • glutaminyl cyclase-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161078 QP5038 99.51% Unkown
HY-161077 QP5020 / Unkown
HY-RS11502 QPCTL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17206 Qpctl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23658 Qpctl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta QPCTL VGNC VGNC:76540
Rattus norvegicus QPCTL RGD RGD:1308128
Bos taurus QPCTL VGNC VGNC:33599
Mus musculus QPCTL MGD MGI:1914619
Felis catus QPCTL VGNC VGNC:64457
Canis familiaris QPCTL VGNC VGNC:45234
Others QPCTL NCBI