EXD2 - exonuclease 3'-5' domain containing 2 Gene

Also Known as EXDL2; C14orf114

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55218

About EXD2

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,191,498-69,244,018 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 9.7), brain (RPKM 8.0) and 25 other tissues.

Summary

Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in nucleic acid metabolic process. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

EXD2 Products (5)

mRNA Protein Name
NM_001193360.2 NP_001180289.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193361.2 NP_001180290.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193362.2 NP_001180291.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193363.2 NP_001180292.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_018199.4 NP_060669.1 exonuclease 3'-5' domain-containing protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' exonuclease activity IDA
IDA: Inferred from direct assay
26807646 GOA
enables 3'-5' exonuclease activity IMP
IMP: Inferred from mutant phenotype
31255466 GOA
enables 3'-5'-DNA exonuclease activity IDA
IDA: Inferred from direct assay
31127291 GOA
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
31127291 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
31127291 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
31127291 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26807646 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
31127291 GOA
enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
IDA: Inferred from direct assay
26807646 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA double-strand break processing IDA
IDA: Inferred from direct assay
26807646 GOA
involved in double-strand break repair IDA
IDA: Inferred from direct assay
26807646 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
26807646 GOA
involved in nucleic acid metabolic process IDA
IDA: Inferred from direct assay
26807646 GOA
involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
31255466 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
29599527 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
31255466 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXD2 Protein Structure

DNA_pol_A_exo1

DNA_pol_A_exo1: 3'-5' exonuclease (96 - 257)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 621 a.a.
Protein Preferred Names Protein Names

exonuclease 3'-5' domain-containing protein 2

  • 3'-5' exoribonuclease EXD2

EXD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EXD2 Q9NVH0 RBBP8 Homo sapiens Q99708
Anti Tag CoIP
26807646
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hereditary Breast Ovarian Cancer Syndrome

  • Hereditary Breast And Ovarian Cancer Syndrome

  • Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

  • Breast And/Or Ovarian Cancer

  • Breast And Ovarian Cancer Syndrome

  • Hboc Syndrome

  • Hereditary Breast And Ovarian Cancer

  • Brca1- Brca2-Associated Hboc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04583 EXD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EXD2 RGD RGD:1311087
Macaca mulatta EXD2 VGNC VGNC:81401
Canis familiaris EXD2 VGNC VGNC:40509
Felis catus EXD2 VGNC VGNC:80976
Bos taurus EXD2 VGNC VGNC:28640
Mus musculus EXD2 MGD MGI:1922485
Others EXD2 NCBI