EXD2 - exonuclease 3'-5' domain containing 2 Gene

Homo sapiens

Also known as EXDL2; C14orf114

Gene ID: 55218 | Gene type: protein coding

About EXD2

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,191,498-69,244,018 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 9.7), brain (RPKM 8.0) and 25 other tissues.

Summary

Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in nucleic acid metabolic process. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

EXD2 Products(5)

mRNA	Protein	Name
NM_001193360.2	NP_001180289.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193361.2	NP_001180290.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193362.2	NP_001180291.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193363.2	NP_001180292.1	exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_018199.4	NP_060669.1	exonuclease 3'-5' domain-containing protein 2 isoform 2

EXD2 Protein Structure

DNA_pol_A_exo1

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

exonuclease 3'-5' domain-containing protein 2

3'-5' exoribonuclease EXD2

Related Diseases

Diseases

Alias

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04583	EXD2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EXD2	RGD	RGD:1311087
Macaca mulatta	EXD2	VGNC	VGNC:81401
Canis familiaris	EXD2	VGNC	VGNC:40509
Felis catus	EXD2	VGNC	VGNC:80976
Bos taurus	EXD2	VGNC	VGNC:28640
Mus musculus	EXD2	MGD	MGI:1922485