YY1AP1 - YY1 associated protein 1 Gene

Also Known as GRNG; HCCA1; HCCA2; YY1AP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55249

About YY1AP1

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,659,442-155,688,996 (from NCBI)

This gene has 25 transcripts (splice variants), 156 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 35.6), bone marrow (RPKM 27.3) and 25 other tissues.

Summary

The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

YY1AP1 Products (12)

mRNA Protein Name
NM_001198899.2 NP_001185828.1 YY1-associated protein 1 isoform 1
NM_001198900.2 NP_001185829.1 YY1-associated protein 1 isoform 1
NM_001198901.2 NP_001185830.1 YY1-associated protein 1 isoform 3
NM_001198902.2 NP_001185831.1 YY1-associated protein 1 isoform 3
NM_001198903.1 NP_001185832.1 YY1-associated protein 1 isoform 6
NM_001198904.1 NP_001185833.1 YY1-associated protein 1 isoform 7
NM_001198905.2 NP_001185834.1 YY1-associated protein 1 isoform 8
NM_001198906.2 NP_001185835.1 YY1-associated protein 1 isoform 9
NM_018253.4 NP_060723.2 YY1-associated protein 1 isoform 1
NM_139118.3 NP_620829.1 YY1-associated protein 1 isoform 2
NM_139119.3 NP_620830.1 YY1-associated protein 1 isoform 3
NM_139121.3 NP_620832.1 YY1-associated protein 1 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14744866 GOA
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IMP
IMP: Inferred from mutant phenotype
27939641 GOA
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
27939641 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
17541814 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
27939641 GOA
Cellular Component GO Annotation Evidence References Source
part of Ino80 complex IDA
IDA: Inferred from direct assay
27939641 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
27939641 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
27939641 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17541814 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

YY1-associated protein 1

  • hepatocellular carcinoma susceptibility protein

YY1AP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
YY1AP1 Q9H869 YY1 Homo sapiens P25490
Confocal
27939641
Intra
YY1AP1 Q9H869 YY1 Homo sapiens P25490
Anti Bait CoIP
27939641
Intra
YY1AP1 Q9H869 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Grange Syndrome

  • Arterial Occlusive Disease, Progressive, With Hypertension, Heart Defects, Bone Fragility, And Brachysyndactyly

  • Grange Occlusive Arterial Syndrome

  • GRNG

  • Progressive Arterial Occlusive Disease-Hypertension-Heart Defects-Bone Fragility-Brachysyndactyly Syndrome
Fibromuscular Dysplasia
Brachydactyly
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Moyamoya Disease 1

  • Moyamoya Disease

  • Spontaneous Occlusion Of The Circle Of Willis

  • Mymy

  • Progressive Intracranial Arterial Occlusion

  • Moyamoya Syndrome

  • MYMY1

  • Cerebrovascular Moyamoya Disease

  • Moya-Moya Disease

  • Progressive Intracranial Occlusive Arteropathy

  • Idiopathic Moyamoya Disease
Chromosome 2q35 Duplication Syndrome

  • Syndactyly

  • Syndactyly Type 1

  • Sdty1

  • Zygodactyly

  • Syndactyly, Type I

  • Sd1

  • Syndactyly, Type 1, With Or Without Craniosynostosis

  • Symphalangism

  • Non-Syndromic Syndactyly

  • Symphalangy

  • Webbing Of Digits

  • Syndactyly, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15947 YY1AP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus YY1AP1 MGD MGI:1917579
Macaca mulatta YY1AP1 VGNC VGNC:78428
Others YY1AP1 NCBI