PGM2 - phosphoglucomutase 2 Gene

Also Known as MSTP006

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55276

About PGM2

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:37,826,686-37,862,937 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 6 paralogues. Ubiquitous expression in esophagus (RPKM 28.0), urinary bladder (RPKM 13.5) and 23 other tissues.

Summary

Enables phosphopentomutase activity. Predicted to be involved in carbohydrate metabolic process and deoxyribose phosphate catabolic process. Predicted to act upstream of or within glucose metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

PGM2 Products (1)

mRNA Protein Name
NM_018290.4 NP_060760.2 phosphopentomutase

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoglucomutase activity IDA
IDA: Inferred from direct assay
17804405 GOA
enables phosphopentomutase activity IDA
IDA: Inferred from direct assay
17804405 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17804405 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGM2 Protein Structure

PGM_PMM_I

PGM_PMM_I: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I (54 - 200)

PGM_PMM_II

PGM_PMM_II: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II (228 - 333)

PGM_PMM_III

PGM_PMM_III: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III (344 - 471)

PGM_PMM_IV

PGM_PMM_IV: Phosphoglucomutase/phosphomannomutase, C-terminal domain (540 - 573)

  • 0
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  • 200
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  • 400
  • 500
  • 612 a.a.
Protein Preferred Names Protein Names

phosphopentomutase

phosphoglucomutase-2

  • PGM 2

PGM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PGM2 Q96G03 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PGM2 Proteins

Cat. No. Product Name Accession Purity
HY-P71201 PGM2 Protein, Human (His) AAH10087.1 (M1-D612) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10390 PGM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10391 PGM2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19932 Pgm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20324 Pgm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21170 Pgm2l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26832 Pgm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27687 Pgm2l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PGM2 VGNC VGNC:44464
Felis catus PGM2 VGNC VGNC:68818
Bos taurus PGM2 VGNC VGNC:32794
Mus musculus PGM2 MGD MGI:97564
Macaca mulatta PGM2 VGNC VGNC:75969
Rattus norvegicus PGM2 RGD RGD:1306061
Others PGM2 NCBI