PPP3R1 - protein phosphatase 3 regulatory subunit B, alpha Gene

Also Known as CNB; CNB1; CALNB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5534

About PPP3R1

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:68,178,857-68,252,532 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 81.4), fat (RPKM 34.1) and 24 other tissues.

Summary

Enables cyclosporin A binding activity; Phosphatase binding activity; and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of Calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]

PPP3R1 Products (1)

mRNA Protein Name
NM_000945.4 NP_000936.1 calcineurin subunit B type 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IPI
IPI: Inferred from physical interaction
26794871 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8524402 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
20639889 GOA
Biological Process GO Annotation Evidence References Source
involved in calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
22688515 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22688515 GOA
Cellular Component GO Annotation Evidence References Source
part of calcineurin complex IDA
IDA: Inferred from direct assay
12218175 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcineurin subunit B type 1

  • calcineurin B, type I (19kDa)

PPP3R1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209-2
Validated Y2H
32296183
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209-2
Y2H Array
32296183
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209-2
Y2H Prey Pooling
32296183
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209-1
X-Ray Diffraction
23468591
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209-1
GMS
23468591
Intra
PPP3R1 P63098 PPP3CC Homo sapiens P48454
Y2H Prey Pooling
32296183
Intra
PPP3R1 P63098 PPP3CC Homo sapiens P48454
Y2H Array
32296183
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209
BRET
37398436
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209
Pull Down
19896943
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209
Y2H Array
25416956
Intra
PPP3R1 P63098 PPP3CA Homo sapiens Q08209
Y2H Prey Pooling
25416956
Intra
PPP3R1 P63098 MAP3K5 Homo sapiens Q99683
Anti Bait CoIP
16648474
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPP3R1 Proteins

Cat. No. Product Name Accession Purity
HY-P7705 Calcineurin B Protein, Human (His) P63098 (M1-V170) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Spinocerebellar Ataxia, X-Linked 3

  • Scax3

  • X-Linked Spinocerebellar Ataxia 3

  • X-Linked Ataxia-Deafness Syndrome

  • X-Linked Spinocerebellar Ataxia Type 3

  • Ataxia-Deafness Syndrome, X-Linked

  • Spinocerebellar Ataxia X-Linked Type 3

  • Ataxia-Deafness Syndrome X-Linked

  • X-Linked Ataxia-Hearing Loss Syndrome

  • Spinocerebellar Ataxia, X-Linked, 3
Spinocerebellar Ataxia, X-Linked 4

  • Scax4

  • X-Linked Spinocerebellar Ataxia 4

  • X-Linked Ataxia-Dementia Syndrome

  • X-Linked Spinocerebellar Ataxia Type 4

  • Ataxia-Dementia Syndrome, X-Linked

  • Spinocerebellar Ataxia X-Linked Type 4

  • Ataxia-Dementia Syndrome X-Linked

  • Spinocerebellar Ataxia, X-Linked, 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11026 PPP3R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21913 Ppp3r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28430 Ppp3r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PPP3R1 VGNC VGNC:108213
Mus musculus PPP3R1 MGD MGI:107172
Rattus norvegicus PPP3R1 RGD RGD:69230
Bos taurus PPP3R1 VGNC VGNC:50247
Others PPP3R1 NCBI