DDX43 - DEAD-box helicase 43 Gene

Also Known as CT13; HAGE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55510

About DDX43

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,394,828-73,417,566 (from NCBI)

This gene has 3 transcripts (splice variants), 33 orthologues and 38 paralogues. Biased expression in testis (RPKM 12.4), placenta (RPKM 1.9) and 3 other tissues.

Summary

The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. [provided by RefSeq, Jul 2008]

DDX43 Products (1)

mRNA Protein Name
NM_018665.3 NP_061135.2 probable ATP-dependent RNA helicase DDX43

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX43 Protein Structure

KH_1

KH_1: KH domain (76 - 128)

DEAD

DEAD: DEAD/DEAH box helicase (266 - 436)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (511 - 582)

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  • 648 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX43

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 43

DDX43 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DDX43 Q9NXZ2 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
DDX43 Q9NXZ2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
DDX43 Q9NXZ2 DDX53 Homo sapiens Q86TM3
Anti Tag CoIP
28514442
Intra
DDX43 Q9NXZ2 DDX53 Homo sapiens Q86TM3
Anti Tag CoIP
33961781
Intra
DDX43 Q9NXZ2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
DDX43 Q9NXZ2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Latent Syphilis

  • Syphilis, Latent
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03651 DDX43 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DDX43 VGNC VGNC:102412
Mus musculus DDX43 MGD MGI:3642857
Rattus norvegicus DDX43 RGD RGD:1586947
Macaca mulatta DDX43 VGNC VGNC:71662
Others DDX43 NCBI