UBE2Q1 - ubiquitin conjugating enzyme E2 Q1 Gene

Also Known as GTAP; NICE5; UBE2Q; NICE-5; PRO3094

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55585

About UBE2Q1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,548,577-154,558,662 (from NCBI)

This gene has 7 transcripts (splice variants), 130 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 25.0), lymph node (RPKM 18.1) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]

UBE2Q1 Products (1)

mRNA Protein Name
NM_017582.7 NP_060052.3 ubiquitin-conjugating enzyme E2 Q1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16275660 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2Q1 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (317 - 406)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 422 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 Q1

  • E2 ubiquitin-conjugating enzyme Q1

UBE2Q1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2Q1 Q7Z7E8 STUB1 Homo sapiens Q9UNE7
Y2H
16275660
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15358 UBE2Q1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBE2Q1 RGD RGD:1305305
Canis familiaris UBE2Q1 VGNC VGNC:48061
Macaca mulatta UBE2Q1 VGNC VGNC:78984
Felis catus UBE2Q1 VGNC VGNC:66763
Mus musculus UBE2Q1 MGD MGI:1917343
Bos taurus UBE2Q1 VGNC VGNC:36592
Others UBE2Q1 NCBI