ITLN1 - intelectin 1 Gene

Also Known as HL1; LFR; HL-1; INTL; ITLN; hIntL; omentin

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55600

About ITLN1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,876,540-160,885,180 (from NCBI)

This gene has 3 transcripts (splice variants), 259 orthologues and 1 paralogue. Biased expression in colon (RPKM 361.8), small intestine (RPKM 202.0) and 3 other tissues.

Summary

Enables calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Involved in positive regulation of glucose import; positive regulation of protein phosphorylation; and protein homotrimerization. Located in extracellular exosome. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

ITLN1 Products (1)

mRNA Protein Name
NM_017625.3 NP_060095.2 intelectin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
26148048 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26148048 GOA
enables oligosaccharide binding IDA
IDA: Inferred from direct assay
26148048 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26819645 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of D-glucose import IDA
IDA: Inferred from direct assay
16531507 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
16531507 GOA
involved in protein homotrimerization IDA
IDA: Inferred from direct assay
26148048 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intelectin-1

  • ITLN-1

ITLN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ITLN1 Q8WWA0 DNAJC12 Homo sapiens Q9UKB3
Anti Tag CoIP
28514442
Intra
ITLN1 Q8WWA0 ITLN2 Homo sapiens Q8WWU7
Anti Tag CoIP
33961781
Intra
ITLN1 Q8WWA0 HSPA5 Homo sapiens P11021
Anti Tag CoIP
33961781
Intra
ITLN1 Q8WWA0 DNAJC12 Homo sapiens Q9UKB3
Anti Tag CoIP
33961781
Intra
ITLN1 Q8WWA0 ITLN1 Homo sapiens Q8WWA0
Comigration in SDS
26148048
Intra
ITLN1 Q8WWA0 ITLN2 Homo sapiens Q8WWU7
Anti Tag CoIP
28514442
Intra
ITLN1 Q8WWA0 ENDOG Homo sapiens Q14249
Anti Tag CoIP
33961781
Intra
ITLN1 Q8WWA0 NACC1 Homo sapiens Q96RE7
Anti Tag CoIP
28514442
Intra
ITLN1 Q8WWA0 NACC1 Homo sapiens Q96RE7
Anti Tag CoIP
33961781
Intra
ITLN1 Q8WWA0 HSPA5 Homo sapiens P11021
Anti Tag CoIP
28514442
Intra
ITLN1 Q8WWA0 ENDOG Homo sapiens Q14249
Anti Tag CoIP
28514442
Intra
ITLN1 Q8WWA0 ITLN1 Homo sapiens Q8WWA0
X-Ray Diffraction
26148048
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pleuropneumonia
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Nonobstructive Coronary Artery Disease

  • Non-Cad

  • Non-Obstructive Coronary Artery Disease
Leptin Deficiency Or Dysfunction

  • Morbid Obesity

  • Obesity Due To Congenital Leptin Deficiency

  • LEPD

  • Congenital Leptin Deficiency

  • Obesity, Morbid

  • Obesity, Morbid, Due To Leptin Deficiency

  • Severe Obesity

  • Obesity, Morbid, Nonsyndromic 1

  • Leptin Deficiency

  • Obesity, Severe, Due To Leptin Deficiency

  • Leptin

  • Morbid Obesity Due To Leptin Deficiency

  • Obesity Morbid

  • Leptin Dysfunction
Diabetes Mellitus

  • Diabetes
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Cardiovascular Disease

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06982 ITLN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20430 Itln1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26939 Itln1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ITLN1 RGD RGD:1561048
Macaca mulatta ITLN1 VGNC VGNC:99984
Mus musculus ITLN1 MGD MGI:1333831
Others ITLN1 NCBI