2. Gene
  3. MAPK4 - mitogen-activated protein kinase 4 Gene

MAPK4 - mitogen-activated protein kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ERK4; ERK-4; PRKM4; p63MAPK; p63-MAPK

Gene ID: 5596 | Gene type: protein coding

About MAPK4

Cytogenetic location: 18q21.1-q21.2 Genomic coordinates (GRCh38): 18:50,559,612-50,731,826 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 207 orthologues and 19 paralogues. Biased expression in adrenal (RPKM 3.2), brain (RPKM 3.1) and 11 other tissues.

Summary

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

MAPK4 Products(3)

mRNA Protein Name
NM_001292039.2 NP_001278968.1 mitogen-activated protein kinase 4 isoform 2
NM_001292040.2 NP_001278969.1 mitogen-activated protein kinase 4 isoform 3
NM_002747.4 NP_002738.2 mitogen-activated protein kinase 4 isoform 1

MAPK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 312)

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  • 587 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 4

Erk3-related

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-154987 MARK4 inhibitor 3 Inhibitor / Unkown
HY-RS08116 MAPK4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAPK4 RGD RGD:3047
Canis familiaris MAPK4 VGNC VGNC:42998
Mus musculus MAPK4 MGD MGI:2444559
Bos taurus MAPK4 VGNC VGNC:31220
Macaca mulatta MAPK4 VGNC VGNC:74647
Felis catus MAPK4 VGNC VGNC:68169
Others MAPK4 NCBI