Txnip - thioredoxin interacting protein Gene

Also Known as THIF; Tbp-2; VDUP1; Hyplip1; 1200008J08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56338

Summary

Enables enzyme inhibitor activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Reye syndrome and hepatocellular carcinoma. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Txnip Products (2)

mRNA Protein Name
NM_001009935.2 NP_001009935.1 thioredoxin-interacting protein isoform 1
NM_023719.2 NP_076208.2 thioredoxin-interacting protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
10843682 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10843682 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18555775 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
18555775 MGI
acts upstream of or within response to oxidative stress IDA
IDA: Inferred from direct assay
10843682 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10843682 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin-interacting protein

  • hyperlipidemia 1

  • thioredoxin binding protein-2

  • upregulated by 1,25-dihydroxyvitamin D-3

  • vitamin D3 up-regulated protein 1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0004 Doxofylline 99.97% Yes

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19330 DASA-58 Activator 99.57% Unkown
HY-141623 SRI-37330 hydrochloride Inhibitor 99.72% Unkown
HY-142114 SRI-37330 Inhibitor 99.16% Unkown
HY-113328 Aminoadipic acid 99.94% Unkown
HY-N0496 Ruscogenin Inhibitor 99.85% Unkown
HY-122682 SBI-993 98.79% Unkown
HY-115688 TXNIP-IN-1 Inhibitor 99.19% Unkown
HY-124418 SBI-477 Inhibitor 98.0% Unkown
HY-155248 HL23 99.64% Unkown
HY-115688A (S)-TXNIP-IN-1 Control 99.73% Unkown
HY-RS16561 Txnip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15295 TXNIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Z15823 (R)-Verapamil 98.97% Unkown
HY-123996 3-Ethoxy-5,6-dibromosalicylaldehyde / Unkown
HY-149216 Anticancer agent 103 / Unkown
HY-169298 Ferroptosis-IN-15 Inhibitor / Unkown
HY-181335 SKL1223 Inhibitor / Unkown
HY-RS22993 Txnip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Txnip NCBI NCBI:10628