Rapgef4 - Rap guanine nucleotide exchange factor (GEF) 4 Gene

Also Known as Epac2; EPAC 2; Epac-2; mKIAA4040; 1300003D15Rik; 5730402K07Rik; 6330581N18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56508

Summary

Enables cAMP binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in regulation of synaptic vesicle cycle. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Located in cytosol and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including adrenal gland; ganglia; heart; lung; and metanephros. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef4 Products (5)

mRNA Protein Name
NM_001204165.1 NP_001191094.1 rap guanine nucleotide exchange factor 4 isoform 1
NM_001204166.1 NP_001191095.1 rap guanine nucleotide exchange factor 4 isoform 3
NM_001204167.1 NP_001191096.1 rap guanine nucleotide exchange factor 4 isoform 4
NM_001355478.1 NP_001342407.1 rap guanine nucleotide exchange factor 4 isoform 5
NM_019688.2 NP_062662.1 rap guanine nucleotide exchange factor 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cAMP binding IDA
IDA: Inferred from direct assay
18660803 MGI
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
11056535 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12401793 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
11056535 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
18660803 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11598134 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11598134 MGI
acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11056535 MGI
acts upstream of or within calcium-ion regulated exocytosis IDA
IDA: Inferred from direct assay
11056535 MGI
acts upstream of or within positive effect hormone secretion IMP
IMP: Inferred from mutant phenotype
23542788 MGI
acts upstream of or within insulin secretion IDA
IDA: Inferred from direct assay
11598134 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
11598134 MGI
acts upstream of or within regulation of exocytosis IDA
IDA: Inferred from direct assay
12401793 MGI
involved in regulation of synaptic vesicle cycle IDA
IDA: Inferred from direct assay
25904804 MGI
involved in regulation of synaptic vesicle cycle IMP
IMP: Inferred from mutant phenotype
25904804 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
11056535 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11056535 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
25904804 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
25904804 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rap guanine nucleotide exchange factor 4

  • cAMP-GEFII

  • cAMP-dependent Rap1 guanine-nucleotide exchange factor

  • cAMP-regulated guanine nucleotide exchange factor IIB

  • exchange factor directly activated by cAMP 2

  • exchange protein directly activated by cAMP 2

Rapgef4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Rapgef4 Q9EQZ6 HRAS Homo sapiens P01112
Pull Down
16316996
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11663 RAPGEF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21252 Rapgef4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27769 Rapgef4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rapgef4 NCBI NCBI:11069