Stap1 - signal transducing adaptor family member 1 Gene

Also Known as Brdg1; STAP-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56792

Summary

Enables macrophage colony-stimulating factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of macrophage migration; and positive regulation of cellular component organization. Acts upstream of or within response to bacterium and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human STAP1 (signal transducing adaptor family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Stap1 Products (2)

mRNA	Protein	Name
NM_001310639.1	NP_001297568.1	signal-transducing adaptor protein 1 isoform 2
NM_019992.4	NP_064376.1	signal-transducing adaptor protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables macrophage colony-stimulating factor receptor binding	IPI IPI: Inferred from physical interaction	19100238	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10679268	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	10679268	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	19100238	MGI
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA IDA: Inferred from direct assay	19100238	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	10679268	MGI
involved in cell surface receptor protein tyrosine kinase signaling pathway	IDA IDA: Inferred from direct assay	19100238	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19100238	MGI
involved in negative regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	19100238	MGI
involved in negative regulation of macrophage colony-stimulating factor signaling pathway	IMP IMP: Inferred from mutant phenotype	19100238	MGI
involved in negative regulation of microglial cell migration	IMP IMP: Inferred from mutant phenotype	19100238	MGI
involved in negative regulation of phosphorylation	IDA IDA: Inferred from direct assay	19100238	MGI
involved in negative regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	19100238	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19100238	MGI
involved in positive regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	19100238	MGI
involved in positive regulation of microglial cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	19100238	MGI
involved in positive regulation of phagocytosis, engulfment	IDA IDA: Inferred from direct assay	19100238	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
signal-transducing adaptor protein 1	BCR downstream signaling 1 stem cell adaptor protein STAP-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13873	STAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15591	UXT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20497	Stap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27005	Stap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stap1	NCBI	NCBI:26228