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PSMB2 - proteasome 20S subunit beta 2 Gene

Also Known as HC7-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5690

About PSMB2

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,599,541-35,641,526 (from NCBI)

This gene has 3 transcripts (splice variants), 220 orthologues and 18 paralogues. Ubiquitous expression in placenta (RPKM 11.8), lymph node (RPKM 10.8) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PSMB2 Products (3)

mRNA	Protein	Name
NM_001199779.2	NP_001186708.1	proteasome subunit beta type-2 isoform 2
NM_001199780.2	NP_001186709.1	proteasome subunit beta type-2 isoform 3
NM_002794.5	NP_002785.1	proteasome subunit beta type-2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14733938	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB2 Protein Structure

Proteasome

0
100
201 a.a.

Protein Preferred Names	Protein Names
proteasome subunit beta type-2	macropain subunit C7-I

PSMB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMB2	P49721	KRT13	Homo sapiens	A1A4E9	Y2H Array	25416956
Intra	PSMB2	P49721	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	PSMB2	P49721	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	PSMB2	P49721	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	PSMB2	P49721	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	PSMB2	P49721	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	PSMB2	P49721	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	PSMB2	P49721	KRTAP19-6	Homo sapiens	Q3LI70	Validated Y2H	32296183
Intra	PSMB2	P49721	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	PSMB2	P49721	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	PSMB2	P49721	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	PSMB2	P49721	KRTAP19-1	Homo sapiens	Q8IUB9	Validated Y2H	32296183
Intra	PSMB2	P49721	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	PSMB2	P49721	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	33961781
Intra	PSMB2	P49721	PSMB5	Homo sapiens	P28074	Y2H	14733938
Intra	PSMB2	P49721	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	28514442
Intra	PSMB2	P49721	PSMB5	Homo sapiens	P28074	Pull Down	35858375
Intra	PSMB2	P49721	PSMA1	Homo sapiens	P25786	Pull Down	35858375
Intra	PSMB2	P49721	PSMA1	Homo sapiens	P25786	Anti Tag CoIP	33961781
Intra	PSMB2	P49721	PSMA1	Homo sapiens	P25786	Y2H	14733938
Intra	PSMB2	P49721	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	33961781
Intra	PSMB2	P49721	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	28514442
Intra	PSMB2	P49721	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	35271311
Intra	PSMB2	P49721	PSMB1	Homo sapiens	P20618	Y2H	17948026
Intra	PSMB2	P49721	PSMB1	Homo sapiens	P20618	Pull Down	35858375
Intra	PSMB2	P49721	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	PSMB2	P49721	KCTD9	Homo sapiens	Q7L273	Validated Y2H	25416956
Intra	PSMB2	P49721	AXIN2	Homo sapiens	Q9Y2T1	Y2H Prey Pooling	32296183
Intra	PSMB2	P49721	AXIN2	Homo sapiens	Q9Y2T1	Y2H Array	32296183
Intra	PSMB2	P49721	AXIN2	Homo sapiens	Q9Y2T1	Validated Y2H	32296183
Intra	PSMB2	P49721	PSMB3	Homo sapiens	P49720	Anti Tag CoIP	33961781
Intra	PSMB2	P49721	PSMB3	Homo sapiens	P49720	Y2H	14733938
Intra	PSMB2	P49721	PSMB3	Homo sapiens	P49720	Anti Tag CoIP	28514442
Intra	PSMB2	P49721	PSMB3	Homo sapiens	P49720	Pull Down	35858375
Intra	PSMB2	P49721	PSMB3	Homo sapiens	P49720	Y2H	17948026
Intra	PSMB2	P49721	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	PSMB2	P49721	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	PSMB2	P49721	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	PSMB2	P49721	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	35271311
Intra	PSMB2	P49721	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	33961781
Intra	PSMB2	P49721	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811229	PSMB2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P87015	PSMB2 Antibody (YA6708)	WB	Human

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11302	PSMB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSMB2	VGNC	VGNC:76443
Felis catus	PSMB2	VGNC	VGNC:69108
Mus musculus	PSMB2	MGD	MGI:1347045
Rattus norvegicus	PSMB2	RGD	RGD:61874
Bos taurus	PSMB2	VGNC	VGNC:33446
Canis familiaris	PSMB2	VGNC	VGNC:45095
Others	PSMB2	NCBI