FEM1C - fem-1 homolog C Gene

Also Known as FEM1A; EUROIMAGE686608; EUROIMAGE783647

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56929

About FEM1C

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,520,908-115,544,775 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 24.9), testis (RPKM 9.4) and 25 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol and nucleoplasm. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

FEM1C Products (1)

mRNA Protein Name
NM_020177.3 NP_064562.1 protein fem-1 homolog C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
26138980 GOA
Biological Process GO Annotation Evidence References Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
26138980 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: Inferred from direct assay
29775578 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
26138980 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEM1C Protein Structure

Ank_4

Ank_4: Ankyrin repeats (many copies) (5 - 61)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (88 - 178)

Ank

Ank: Ankyrin repeat (182 - 206)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (481 - 557)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
Protein Preferred Names Protein Names

protein fem-1 homolog C

  • FEM1-gamma

FEM1C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FEM1C Q96JP0 RPGRIP1 Homo sapiens Q96KN7
Y2H Prey Pooling
25416956
Intra
FEM1C Q96JP0 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
Intra
FEM1C Q96JP0 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
Intra
FEM1C Q96JP0 CEP63 Homo sapiens Q96MT8-3
Validated Y2H
32296183
Intra
FEM1C Q96JP0 MALT1 Homo sapiens Q9UDY8-2
Validated Y2H
32296183
Intra
FEM1C Q96JP0 MALT1 Homo sapiens Q9UDY8-2
Y2H Prey Pooling
32296183
Intra
FEM1C Q96JP0 MALT1 Homo sapiens Q9UDY8-2
Y2H Array
32296183
Intra
FEM1C Q96JP0 MCM8 Homo sapiens Q9UJA3-4
Validated Y2H
32296183
Intra
FEM1C Q96JP0 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04860 FEM1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FEM1C RGD RGD:1309322
Macaca mulatta FEM1C VGNC VGNC:110466
Bos taurus FEM1C VGNC VGNC:28946
Mus musculus FEM1C MGD MGI:2444737
Felis catus FEM1C VGNC VGNC:62225
Canis familiaris FEM1C VGNC VGNC:51719
Others FEM1C NCBI