YAE1 - YAE1 maturation factor of ABCE1 Gene

Also Known as CIAB2; GK003; YAE1D1; C7orf36

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57002

About YAE1

This gene has 6 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in testis (RPKM 3.0), endometrium (RPKM 2.4) and 25 other tissues.

Summary

Involved in protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

YAE1 Products (2)

mRNA Protein Name
NM_001282446.2 NP_001269375.1 protein YAE1 homolog isoform 2
NM_020192.5 NP_064577.1 protein YAE1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in protein maturation by [4Fe-4S] cluster transfer IDA
IDA: Inferred from direct assay
26182403 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YAE1 Protein Structure

Yae1_N

Yae1_N: Essential protein Yae1, N terminal (45 - 82)

  • 0
  • 100
  • 200
  • 226 a.a.
Protein Preferred Names Protein Names

protein YAE1 homolog

  • YAE1, ABCE1 maturation factor

YAE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
YAE1 Q9NRH1 LTO1 Homo sapiens Q8WV07
Y2H Array
32296183
Intra
YAE1 Q9NRH1 LTO1 Homo sapiens Q8WV07
Y2H Prey Pooling
32296183
Intra
YAE1 Q9NRH1 EXOC7 Homo sapiens Q9UPT5-1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichothiodystrophy 4, Nonphotosensitive

  • Amish Brittle Hair Brain Syndrome

  • TTD4

  • Trichothiodystrophy, Nonphotosensitive 1

  • Hair-Brain Syndrome

  • Bids Syndrome

  • Ttdn1

  • Abhs

  • Pollitt Syndrome

  • Trichothiodystrophy-Neurocutaneous Syndrome

  • Nonphotosensitive Trichothiodystrophy 4

  • Trichorrhexis Nodosa Syndrome

  • Trichothiodystrophy 4, Non-Photosensitive

  • Trichothiodystrophy Non-Photosensitive 1
Trichothiodystrophy 1, Photosensitive

  • TTD1

  • Tay Syndrome

  • Trichothiodystrophy With Congenital Ichthyosis

  • Photosensitive Trichothiodystrophy

  • Ibids Syndrome

  • Ttdp

  • Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation

  • Ichthyosis, Congenital, With Trichothiodystrophy

  • Pibids Syndrome

  • Photosensitive Trichothiodystrophy 1

  • Trichothiodystrophy, Photosensitive

  • Sulfur-Deficient Brittle Hair Syndrome

  • Ttd-P

  • Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature

  • Trichothiodystrophy Photosensitive

  • Trichothiodystrophy, Type 1

  • Tricho-Thiodystrophy Disorder

  • Trichothiodystrophy Syndromes

  • Amish Brittle Hair Brain Syndrome
Nonphotosensitive Trichothiodystrophy

  • Trichothiodystrophy Nonphotosensitive

  • Amish Brittle Hair Brain Syndrome
Trichothiodystrophy 3, Photosensitive

  • TTD3

  • Trichothiodystrophy, Complementation Group A

  • Ttda

  • Photosensitive Trichothiodystrophy 3

  • Trichothiodystrophy Complementation Group A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15909 YAE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus YAE1 VGNC VGNC:37013
Mus musculus YAE1 MGD MGI:1914258
Canis familiaris YAE1 VGNC VGNC:48477
Macaca mulatta YAE1 VGNC VGNC:79460
Felis catus YAE1 VGNC VGNC:67127
Rattus norvegicus YAE1 RGD RGD:1306613
Others YAE1 NCBI