LTO1 - LTO1 maturation factor of ABCE1 Gene

Also Known as CIAB1; TAOS1; ORAOV1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 220064

About LTO1

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:69,665,563-69,675,353 (from NCBI)

This gene has 18 transcripts (splice variants) and 111 orthologues. Ubiquitous expression in testis (RPKM 2.2), skin (RPKM 2.1) and 25 other tissues.

Summary

Involved in protein maturation by [4Fe-4S] cluster transfer; ribosomal large subunit biogenesis; and translational initiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

LTO1 Products (1)

mRNA Protein Name
NM_153451.3 NP_703152.1 protein LTO1 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24930674 GOA
Biological Process GO Annotation Evidence References Source
involved in protein maturation by [4Fe-4S] cluster transfer IDA
IDA: Inferred from direct assay
26182403 GOA
involved in ribosomal large subunit biogenesis IMP
IMP: Inferred from mutant phenotype
23318452 GOA
involved in translational initiation IMP
IMP: Inferred from mutant phenotype
23318452 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTO1 Protein Structure

Yae1_N

Yae1_N: Essential protein Yae1, N terminal (22 - 60)

  • 0
  • 100
  • 137 a.a.
Protein Preferred Names Protein Names

protein LTO1 homolog

  • LTO1, ABCE1 maturation factor

LTO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LTO1 Q8WV07 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra
LTO1 Q8WV07 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
LTO1 Q8WV07 YAE1 Homo sapiens Q9NRH1
Y2H Prey Pooling
32296183
Intra
LTO1 Q8WV07 YAE1 Homo sapiens Q9NRH1
Validated Y2H
32296183
Intra
LTO1 Q8WV07 YAE1 Homo sapiens Q9NRH1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cone-Rod Dystrophy 3

  • CORD3

  • Dystrophy, Cone Rod, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07886 LTO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LTO1 VGNC VGNC:103111
Macaca mulatta LTO1 VGNC VGNC:74308
Bos taurus LTO1 VGNC VGNC:54908
Canis familiaris LTO1 VGNC VGNC:56091
Mus musculus LTO1 MGD MGI:1919534
Rattus norvegicus LTO1 RGD RGD:1304637
Others LTO1 NCBI