PDXP - pyridoxal phosphatase Gene

Homo sapiens

Also known as CIN; PLP; dJ37E16.5

Gene ID: 57026 | Gene type: protein coding

About PDXP

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,658,723-37,666,932 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 3 paralogues. Broad expression in brain (RPKM 43.8), small intestine (RPKM 14.2) and 21 other tissues.

Summary

Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]

PDXP Products(1)

mRNA	Protein	Name
NM_020315.5	NP_064711.1	chronophin

PDXP Protein Structure

Hydrolase_6

Hydrolase_like

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

chronophin

PLP phosphatase

Related Diseases

Diseases

Alias

Contractural Arachnodactyly, Congenital

Congenital Contractural Arachnodactyly	Beals Syndrome
CCA	Beals-Hecht Syndrome
Distal Arthrogryposis Type 9	Arthrogryposis, Distal, Type 9
Da9	Arachnodactyly, Contractural Beals Type
Contractures, Multiple With Arachnodactyly	Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis
Arthrogyroposis, Distal, Type 9	Distal Arthrogyropsis Type 9
Cca Syndrome	Arachnodactyly

Laurence-Moon Syndrome

LNMS	Laurence-Moon-Biedl Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10298	PDXP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDXP	MGD	MGI:1919282
Rattus norvegicus	PDXP	RGD	RGD:1586212
Bos taurus	PDXP	VGNC	VGNC:32722
Canis familiaris	PDXP	VGNC	VGNC:44397
Others	PDXP	NCBI