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Arrb1 - arrestin, beta 1 Gene

Also Known as BARRES

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25387

Summary

Enables several functions, including AP-2 adaptor complex binding activity; G protein-coupled receptor binding activity; and Arrestin family protein binding activity. Involved in several processes, including regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and regulation of cellular protein metabolic process. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Used to study congestive heart failure. Biomarker of colitis. Orthologous to human ARRB1 (Arrestin beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Arrb1 Products (1)

mRNA	Protein	Name
NM_012910.2	NP_037042.1	beta-arrestin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AP-2 adaptor complex binding	IDA IDA: Inferred from direct assay	15728179	RGD
enables V2 vasopressin receptor binding	IDA IDA: Inferred from direct assay	17513300	RGD
enables alpha-1A adrenergic receptor binding	IPI IPI: Inferred from physical interaction	18523139	RGD
enables alpha-1B adrenergic receptor binding	IDA IDA: Inferred from direct assay	18523139	RGD
enables arrestin family protein binding	IPI IPI: Inferred from physical interaction	23886940	RGD
enables clathrin adaptor activity	IDA IDA: Inferred from direct assay	15728179	RGD
enables clathrin binding	IDA IDA: Inferred from direct assay	17513300	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	12399592	RGD
enables follicle-stimulating hormone receptor binding	IPI IPI: Inferred from physical interaction	16899567	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	19339617	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	11742073	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10725339	RGD
enables protein phosphorylated amino acid binding	IDA IDA: Inferred from direct assay	17513300	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	23604254	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20650893	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	1517224	RGD
involved in endocytosis	IDA IDA: Inferred from direct assay	12519791	RGD
involved in follicle-stimulating hormone signaling pathway	IDA IDA: Inferred from direct assay	16899567	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19254952	RGD
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	1517224	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24378649	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	26621121	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19254952	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19289825	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	12167719	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25486571	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19171933	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24378649	RGD
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	20650893	RGD
involved in positive regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19171933	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16325578	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11742073	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	1517224	RGD
involved in regulation of inositol trisphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	20705669	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	12614678	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	21223624	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16899567	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	1517224	RGD
located in endosome	IDA IDA: Inferred from direct assay	25016018	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	1517224	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	1517224	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	1517224	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
beta-arrestin-1

Arrb1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Arrb1	P29066	TP53	Homo sapiens	P04637	Pull Down	21857681
Cross	Arrb1	P29066	TP53	Homo sapiens	P04637	Anti Tag CoIP	21857681
Cross	Arrb1	P29066	PDXP	Homo sapiens	Q96GD0	Anti Tag CoIP	17500066
Cross	Arrb1	P29066	F2RL1	Homo sapiens	P55085	GMS	10725339
Cross	Arrb1	P29066	F2RL1	Homo sapiens	P55085	Confocal	10725339
Cross	Arrb1	P29066	F2RL1	Homo sapiens	P55085	Anti Tag CoIP	10725339
Cross	Arrb1	P29066	LIMK1	Homo sapiens	P53667	Pull Down	17500066
Intra	Arrb1	P29066	Raf1	Rattus norvegicus	P11345	GMS	10725339
Intra	Arrb1	P29066	Raf1	Rattus norvegicus	P11345	Anti Tag CoIP	10725339
Intra	Arrb1	P29066	Raf1	Rattus norvegicus	P11345	Confocal	10725339

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01028	ARRB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18162	Arrb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24636	Arrb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arrb1	NCBI	NCBI:408