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ERGIC1 - endoplasmic reticulum-golgi intermediate compartment 1 Gene

Also Known as AMC2; AMCN; NET24; ERGIC32; ERGIC-32

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57222

About ERGIC1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,834,251-172,952,683 (from NCBI)

This gene has 30 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in prostate (RPKM 69.0), adrenal (RPKM 49.7) and 25 other tissues.

Summary

This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with Other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]

ERGIC1 Products (1)

mRNA	Protein	Name
NM_001031711.3	NP_001026881.1	endoplasmic reticulum-Golgi intermediate compartment protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15308636	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	15308636	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERGIC1 Protein Structure

ERGIC_N

COPIIcoated_ERV

0
100
200
290 a.a.

Protein Preferred Names	Protein Names
endoplasmic reticulum-Golgi intermediate compartment protein 1	ER-Golgi intermediate compartment 32 kDa protein

ERGIC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ERGIC1	Q969X5	ERGIC3	Homo sapiens	Q9Y282	Crosslink	15308636
Intra	ERGIC1	Q969X5	ERGIC3	Homo sapiens	Q9Y282	IF	15308636

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arthrogryposis Multiplex Congenita 2, Neurogenic Type	Arthrogryposis Multiplex Congenita, Neurogenic Type Amcn Arthrogryposis Multiplex Congenita Neurogenic Type AMC2 Amc, Neurogenic Type Neurogenic-Type Arthrogryposis Multiplex Congenita-2 Amc Neurogenic Type Neurogenic Type Of Amc Neurogenic Arthrogryposis Multiplex Congenita Arthrogryposis Multiplex Congenita, Neurogenic
Distal Arthrogryposis	Arthrogryposis Multiplex Congenita Arthrogryposis Congenital Multiple Arthrogryposis Congenital Arthromyodysplasia Fibrous Ankylosis Of Multiple Joints Guerin-Stern Syndrome Guérin-Stern Syndrome Myodystrophia Fetalis Deformans Otto Syndrome Rocher-Sheldon Syndrome Rossi Syndrome Amc Multiple Congenital Arthrogryposis Arthrogryposis Syndrome Arthrogryposis, Distal Distal Arthrogryposis Syndrome Freeman-Sheldon Syndrome Arthrogryposis, Distal, Type 2b Congenital Multiplex Arthrogryposis Amyoplasia Congenita Congenital Amyoplasia Amc - [Arthrogryposis Multiplex Congenita]
Frank-Ter Haar Syndrome	Ter Haar Syndrome Borrone Dermatocardioskeletal Syndrome FTHS Autosomal Recessive Melnick-Needles Syndrome Borrone Di Rocco Crovato Syndrome Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay Melnick-Needles Syndrome, Autosomal Recessive, Formerly Frank Ter Haar Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04493	ERGIC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ERGIC1	MGD	MGI:1914708
Rattus norvegicus	ERGIC1	RGD	RGD:1585015
Macaca mulatta	ERGIC1	VGNC	VGNC:82141
Felis catus	ERGIC1	VGNC	VGNC:61939
Bos taurus	ERGIC1	VGNC	VGNC:28578
Canis familiaris	ERGIC1	VGNC	VGNC:40450
Others	ERGIC1	NCBI