NMRAL1 - NmrA like redox sensor 1 Gene

Also Known as HSCARG; SDR48A1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57407

About NMRAL1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,461,694-4,476,337 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele and 113 orthologues. Ubiquitous expression in prostate (RPKM 6.2), ovary (RPKM 6.2) and 25 other tissues.

Summary

This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular Antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

NMRAL1 Products (6)

mRNA	Protein	Name
NM_001305141.3	NP_001292070.1	nmrA-like family domain-containing protein 1 isoform 1
NM_001305142.3	NP_001292071.1	nmrA-like family domain-containing protein 1 isoform 1
NM_001351994.2	NP_001338923.1	nmrA-like family domain-containing protein 1 isoform 1
NM_001351995.2	NP_001338924.1	nmrA-like family domain-containing protein 1 isoform 2
NM_001351996.2	NP_001338925.1	nmrA-like family domain-containing protein 1 isoform 3
NM_020677.6	NP_065728.1	nmrA-like family domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17496144	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17496144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMRAL1 Protein Structure

NmrA

0
100
200
299 a.a.

Protein Preferred Names	Protein Names
nmrA-like family domain-containing protein 1	NmrA-like family domain containing 1

NMRAL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NMRAL1	Q9HBL8	NMRAL1	Homo sapiens	Q9HBL8	DLS	17496144
Intra	NMRAL1	Q9HBL8	NMRAL1	Homo sapiens	Q9HBL8	X-Ray Diffraction	17496144
Intra	NMRAL1	Q9HBL8	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	NMRAL1	Q9HBL8	ACTA1	Homo sapiens	P68133	Anti Tag CoIP	33961781
Intra	NMRAL1	Q9HBL8	ASS1	Homo sapiens	P00966	Anti Bait CoIP	17496144
Intra	NMRAL1	Q9HBL8	GALNT1	Homo sapiens	Q10472	Anti Tag CoIP	33961781
Intra	NMRAL1	Q9HBL8	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	NMRAL1	Q9HBL8	ASS1	Homo sapiens	P00966	Anti Tag CoIP	17496144
Intra	NMRAL1	Q9HBL8	TUBA1A	Homo sapiens	Q71U36	Anti Tag CoIP	33961781
Intra	NMRAL1	Q9HBL8	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	33961781
Intra	NMRAL1	Q9HBL8	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09385	NMRAL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19068	Nmral1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25558	Nmral1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NMRAL1	VGNC	VGNC:32134
Macaca mulatta	NMRAL1	VGNC	VGNC:75252
Rattus norvegicus	NMRAL1	RGD	RGD:1311451
Mus musculus	NMRAL1	MGD	MGI:1915074
Canis familiaris	NMRAL1	VGNC	VGNC:103694
Felis catus	NMRAL1	VGNC	VGNC:63841