MIER1 - MIER1 transcriptional regulator Gene

Also Known as ER1; MI-ER1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57708

About MIER1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:66,924,990-66,988,619 (from NCBI)

This gene has 11 transcripts (splice variants), 223 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 19.6), colon (RPKM 10.3) and 24 other tissues.

Summary

This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

MIER1 Products (12)

mRNA Protein Name
NM_001077700.3 NP_001071168.2 mesoderm induction early response protein 1 isoform b
NM_001077701.3 NP_001071169.1 mesoderm induction early response protein 1 isoform c
NM_001077702.3 NP_001071170.2 mesoderm induction early response protein 1 isoform d precursor
NM_001077703.3 NP_001071171.2 mesoderm induction early response protein 1 isoform e
NM_001077704.3 NP_001071172.1 mesoderm induction early response protein 1 isoform f
NM_001146110.2 NP_001139582.1 mesoderm induction early response protein 1 isoform a precursor
NM_001146111.2 NP_001139583.1 mesoderm induction early response protein 1 isoform g precursor
NM_001146112.2 NP_001139584.1 mesoderm induction early response protein 1 isoform h
NM_001146113.2 NP_001139585.1 mesoderm induction early response protein 1 isoform i
NM_001278215.2 NP_001265144.1 mesoderm induction early response protein 1 isoform j precursor
NM_001350530.2 NP_001337459.1 mesoderm induction early response protein 1 isoform k
NM_020948.4 NP_065999.2 mesoderm induction early response protein 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to histone deacetylase activity IDA
IDA: Inferred from direct assay
28046085 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
28046085 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12482978 GOA
Biological Process GO Annotation Evidence Références Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
12482978 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12482978 GOA
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
28046085 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28046085 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
12482978 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIER1 Protein Structure

ELM2

ELM2: ELM2 domain (182 - 234)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 512 a.a.
Protein Preferred Names Protein Names

mesoderm induction early response protein 1

  • mesoderm induction early response 1 homolog

MIER1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MIER1 Q8N108 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
12482978
Intra
MIER1 Q8N108 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
18451879
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 2

  • IBD2
Frozen Shoulder

  • Adhesive Capsulitis Of Shoulder

  • Bursitis

  • Adhesions-Capsulitis,Shoulder

  • Pericapsulitis Of Shoulder

  • Duplay Bursitis

  • Adhesive Shoulder Peritendinitis

  • Subscapular Adhesion

  • Shoulder Adhesion

  • Adhesive Enthesopathy Of Shoulder Region

  • Adhesive Peritendinitis

  • Adhesive Shoulder Tenosynovitis

  • Duplay Periarthritis

  • Adhesive Shoulder Tendinitis
Amelogenesis Imperfecta, Type Ig

  • Enamel-Renal Syndrome

  • Ers

  • Amelogenesis Imperfecta Type 1g

  • AI1G

  • Enamel-Renal-Gingival Syndrome

  • Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

  • Aigfs

  • Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

  • Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

  • Amelogenesis Imperfecta Type Ig

  • Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

  • Amelogenesis Imperfecta 1g

  • Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

  • Amelogenesis Imperfecta Nephrocalcinosis
Calcific Tendinitis

  • Calcific Tendinitis Nos
Teeth Hard Tissue Disease
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08442 MIER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MIER1 VGNC VGNC:31469
Canis familiaris MIER1 VGNC VGNC:43229
Felis catus MIER1 VGNC VGNC:63500
Macaca mulatta MIER1 VGNC VGNC:74862
Rattus norvegicus MIER1 RGD RGD:1562337
Mus musculus MIER1 MGD MGI:1918398
Others MIER1 NCBI