WIZ - WIZ zinc finger Gene

Also Known as ZNF803

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 58525

About WIZ

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,419,978-15,449,956 (from NCBI)

This gene has 12 transcripts (splice variants), 263 orthologues and 51 paralogues. Ubiquitous expression in testis (RPKM 8.9), fat (RPKM 6.6) and 25 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; Histone Methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

WIZ Products (5)

mRNA	Protein	Name
NM_001330395.4	NP_001317324.2	protein Wiz isoform 2
NM_001371589.1	NP_001358518.1	protein Wiz isoform 3
NM_001371603.5	NP_001358532.2	protein Wiz isoform 4
NM_001411129.1	NP_001398058.1	protein Wiz isoform 5
NM_021241.3	NP_067064.2	protein Wiz isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25789554	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25789554	GOA
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	16702210	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16702210	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16702210	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of nuclear cell cycle DNA replication	IMP IMP: Inferred from mutant phenotype	23545495	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	16702210	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	16702210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WIZ Protein Structure

zf-C2H2_4

0
200
400
600
794 a.a.

Protein Preferred Names	Protein Names
protein Wiz	widely interspaced zinc finger motifs

Related Diseases

Diseases	Alias
Autosomal Dominant Wolfram Syndrome
Kleefstra Syndrome	9q34.3 Microdeletion Syndrome 9q Subtelomeric Deletion Syndrome 9q- Syndrome Chromosome 9q Deletion Syndrome 9q34.3 Deletion Syndrome 9qstds Chromosome 9q34.3 Deletion Syndrome Chromosome 9, Trisomy 9q

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159099	WIZ degrader 9	Degrader	99.29%	Unkown
HY-175742	BMS-986470	Degrader	99.78%	Unkown
HY-169761B	(R,R)-dWIZ-1 TFA	Control	98.58%	Unkown
HY-169955A	WIZ degrader 8 TFA	Degrader	99.41%	Unkown
HY-159098	dWIZ-1	Degrader	/	Unkown
HY-169955	WIZ degrader 8	Degrader	98.30%	Unkown
HY-175742A	(R)-BMS-986470		99.93%	Unkown
HY-163820	WIZ degrader 4	Degrader	99.37%	Unkown
HY-162665	WIZ degrader 1	Inducer	/	Unkown
HY-163818	WIZ degrader 2	Degrader	/	Unkown
HY-163819	WIZ degrader 3	Degrader	/	Unkown
HY-169761	(rac)-dWIZ-1	Degrader	/	Unkown
HY-RS15821	WIZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-163822	WIZ degrader 5	Degrader	/	Unkown
HY-163823	WIZ degrader 6	Degrader	/	Unkown
HY-163824	WIZ degrader 7	Degrader	/	Unkown
HY-RS22086	Wiz Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28606	Wiz Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WIZ	VGNC	VGNC:79901
Canis familiaris	WIZ	VGNC	VGNC:106618
Mus musculus	WIZ	MGD	MGI:1332638
Bos taurus	WIZ	VGNC	VGNC:36947
Rattus norvegicus	WIZ	RGD	RGD:1307771
Felis catus	WIZ	VGNC	VGNC:80758
Others	WIZ	NCBI