PZP - PZP alpha-2-macroglobulin like Gene

Homo sapiens

Also known as CPAMD6

Gene ID: 5858 | Gene type: protein coding

About PZP

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,136,472-9,208,395 (from NCBI)

This gene has 7 transcripts (splice variants), 584 orthologues and 8 paralogues. Biased expression in liver (RPKM 5.3), endometrium (RPKM 1.0) and 2 other tissues.

Summary

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]

PZP Products(1)

mRNA	Protein	Name
NM_002864.3	NP_002855.2	pregnancy zone protein precursor

PZP Protein Structure

A2M_N

A2M_N_2

A2M

Thiol-ester_cl

A2M_comp

A2M_recep

0
300
600
900
1200
1482 a.a.

Protein Preferred Names

Protein Names

pregnancy zone protein

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

Related Diseases

Diseases

Alias

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Inflammatory Bowel Disease 17

Inflammatory Bowel Disease 17, Protection Against	IBD17
Bowel Disease, Inflammatory, Type 17

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11498	PZP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PZP	RGD	RGD:621366