PZP - PZP alpha-2-macroglobulin like Gene

Also Known as CPAMD6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5858

About PZP

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,136,472-9,208,395 (from NCBI)

This gene has 7 transcripts (splice variants), 584 orthologues and 8 paralogues. Biased expression in liver (RPKM 5.3), endometrium (RPKM 1.0) and 2 other tissues.

Summary

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]

PZP Products (1)

mRNA Protein Name
NM_002864.3 NP_002855.2 pregnancy zone protein precursor

PZP Protein Structure

A2M_N

A2M_N: MG2 domain (128 - 220)

A2M_N_2

A2M_N_2: Alpha-2-macroglobulin family N-terminal region (455 - 603)

A2M

A2M: Alpha-2-macroglobulin family (744 - 834)

Thiol-ester_cl

Thiol-ester_cl: Alpha-macro-globulin thiol-ester bond-forming region (967 - 997)

A2M_comp

A2M_comp: A-macroglobulin complement component (1016 - 1271)

A2M_recep

A2M_recep: A-macroglobulin receptor (1382 - 1469)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1482 a.a.
Protein Preferred Names Protein Names

pregnancy zone protein

  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

Related Diseases

Diseases Alias
Gestational Trophoblastic Neoplasm

  • Hydatidiform Mole

  • Molar Pregnancy

  • Gestational Trophoblastic Neoplasia

  • Gestational Trophoblastic Tumor

  • Gtn

  • Gestational Trophoblastic Disease

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole Benign

  • Trophoblastic Disease

  • Trophoblastic Disease Nos

  • Trophoblastic Disorder

  • Vesicular Mole Nos

  • Vesicular Mole

  • Hydatidiform Mole Nos
Inflammatory Bowel Disease 17

  • Inflammatory Bowel Disease 17, Protection Against

  • IBD17

  • Bowel Disease, Inflammatory, Type 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11498 PZP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19112 Pzp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25602 Pzp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PZP RGD RGD:621366
Others PZP NCBI