Gas6 - growth arrest specific 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58935

Summary

Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phosphatidylserine binding activity; and signaling receptor binding activity. Involved in several processes, including activation of protein kinase B activity; positive regulation of intracellular signal transduction; and regulation of renal system process. Located in extracellular space. Used to study glomerulonephritis. Orthologous to human GAS6 (growth arrest specific 6). [provided by Alliance of Genome Resources, Apr 2022]

Gas6 Products (1)

mRNA Protein Name
NM_057100.2 NP_476441.2 growth arrest-specific protein 6 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in activation of protein kinase B activity IDA
IDA: Inferred from direct assay
18374201 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16285961 RGD
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
18374201 RGD
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
18374201 RGD
involved in extracellular matrix assembly IEP
IEP: Inferred from expression pattern
18374201 RGD
involved in negative regulation of renal albumin absorption IEP
IEP: Inferred from expression pattern
18374201 RGD
involved in positive regulation of TOR signaling IDA
IDA: Inferred from direct assay
18374201 RGD
involved in positive regulation of glomerular filtration IDA
IDA: Inferred from direct assay
18374201 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
18374201 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18374201 RGD
involved in signal transduction IDA
IDA: Inferred from direct assay
18374201 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18374201 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth arrest-specific protein 6

  • AXL receptor tyrosine kinase ligand

  • GAS-6

  • GPF

  • growth-potentiating factor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-177332 SLC-391 Inhibitor / Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99463 Batiraxcept Inhibitor 99.91% Phase 3
HY-P99161 Tilvestamab Inhibitor 98.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12494 LDC1267 Inhibitor 99.64% Unkown
HY-N2995 Poricoic acid A 99.32% Unkown
HY-119039 RU-301 Inhibitor 99.75% Unkown
HY-124066 RU-302 Inhibitor 98.72% Unkown
HY-149092 Anticancer agent 109 / Unkown
HY-152075 AXL-IN-14 Inhibitor / Unkown
HY-179535 Axl-IN-21 Inhibitor / Unkown
HY-RS05285 GAS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16715 Gas6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23150 Gas6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992231 Anti-GAS6 Antibody (KM5321) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gas6 NCBI NCBI:2621