GAS6 - growth arrest specific 6 Gene

Also Known as AXSF; AXLLG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2621

About GAS6

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,820,549-113,864,076 (from NCBI)

This gene has 5 transcripts (splice variants), 142 orthologues and 3 paralogues. Ubiquitous expression in lung (RPKM 64.9), endometrium (RPKM 57.7) and 24 other tissues.

Summary

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

GAS6 Products (1)

mRNA	Protein	Name
NM_000820.4	NP_000811.1	growth arrest-specific protein 6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16723520	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	21501828	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16362042	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	21501828	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	15184064	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	7634325	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	16359517	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	7854420	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell chemotaxis	IDA IDA: Inferred from direct assay	19922767	GOA
involved in apoptotic cell clearance	IDA IDA: Inferred from direct assay	21501828	GOA
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	18395422	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	20103767	GOA
involved in cellular response to interferon-alpha	IDA IDA: Inferred from direct assay	19657094	GOA
involved in cellular response to vitamin K	IDA IDA: Inferred from direct assay	16359517	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16359517	GOA
involved in dendritic cell differentiation	IEP IEP: Inferred from expression pattern	19657094	GOA
involved in fusion of virus membrane with host plasma membrane	IDA IDA: Inferred from direct assay	21501828	GOA
involved in hematopoietic stem cell migration to bone marrow	IDA IDA: Inferred from direct assay	19922767	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18680538	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19922767	GOA
involved in negative regulation of biomineral tissue development	IDA IDA: Inferred from direct assay	20048160	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16723520	GOA
involved in negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	19657094	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	16359517	GOA
involved in negative regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	16359517	GOA
involved in negative regulation of interleukin-1 production	IDA IDA: Inferred from direct assay	20103767	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	19657094	GOA
involved in negative regulation of oligodendrocyte apoptotic process	IDA IDA: Inferred from direct assay	16723520	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	19657094	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	19657094	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	18840707	GOA
involved in phagocytosis	IDA IDA: Inferred from direct assay	21501828	GOA
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	15184064	GOA
involved in positive regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18840707	GOA
involved in positive regulation of dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	19657094	GOA
acts upstream of or within positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	15184064	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	7854420	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19657094	GOA
involved in positive regulation of natural killer cell differentiation	IDA IDA: Inferred from direct assay	18840707	GOA
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	18395422	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16359517	GOA
involved in positive regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	18680538	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	7854420	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	7854420	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	16359517	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	16359517	GOA
involved in receptor-mediated virion attachment to host cell	IDA IDA: Inferred from direct assay	21501828	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	7854420	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	21501828	GOA
involved in viral genome replication	IDA IDA: Inferred from direct assay	21501828	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18395422	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	8336730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAS6 Protein Structure

Gla

FXa_inhibition

EGF_CA

Laminin_G_1

Laminin_G_2

0
200
400
600
678 a.a.

Protein Preferred Names	Protein Names
growth arrest-specific protein 6	AXL receptor tyrosine kinase ligand

Recombinant GAS6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70470	GAS6 Protein, Human (HEK293, Fc)	Q14393-2 (A31-A678)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70780	GAS6 Protein, Human (HEK293, His, solution)	Q14393-2 (A31-A678)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700724	GAS6 Protein, Human (630a.a, HEK293, His)	Q14393-2 (A49-A678)	≥ 95%, as determined by Bis-Tris PAGE.

GAS6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85881	Gas6 Antibody (YA5573)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Mesangial Proliferative Glomerulonephritis	Glomerulonephritis - Mesangial Proliferative Mesangial Proliferative Gn Mesangioproliferative Glomerulonephritis Glomerulonephritis Mesangial Proliferative
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Vitamin K Deficiency Bleeding	Vitamin K Deficiency Deficiency Of Vitamin K Vitamin K Vitamin K Deficiency Hemorrhagic Disease
Glomerulonephritis	Bright'S Disease
Ciliary Dyskinesia, Primary, 33	Primary Ciliary Dyskinesia 33 CILD33 Ciliary Dyskinesia, Primary, 33, Without Situs Inversus Primary Ciliary Dyskinesia 33 Without Situs Inversus
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Parameningeal Embryonal Rhabdomyosarcoma
La Crosse Encephalitis	California Encephalitis California Virus Encephalitis Neuroinvasive California Encephalitis Virus Infection Californian Encephalitis Encephalitis, California California Meningoencephalitis California Encephalitis Virus Infection California Encephalitis Virus Infection Neuroinvasive Disease California Meningoencephalitis Virus Disease California Serogroup Virus Neuroinvasive Disease California Viral Encephalitis Ce - [California Encephalitis] Lac - [La Crosse Encephalitis]
Meckel Syndrome, Type 7	Meckel Syndrome 7 Nphp3-Related Meckel-Like Syndrome MKS7 Goldston Syndrome Meckel Syndrome Type 7 Meckel-Like Syndrome Type 1 Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst Meckel-Gruber Syndrome, Type 7 Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99463	Batiraxcept	Inhibitor	99.91%	Phase 3
HY-P99161	Tilvestamab	Inhibitor	98.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12494	LDC1267	Inhibitor	99.64%	Unkown
HY-N2995	Poricoic acid A		99.19%	Unkown
HY-119039	RU-301	Inhibitor	99.75%	Unkown
HY-124066	RU-302	Inhibitor	98.72%	Unkown
HY-149092	Anticancer agent 109		/	Unkown
HY-152075	AXL-IN-14	Inhibitor	/	Unkown
HY-179535	Axl-IN-21	Inhibitor	/	Unkown
HY-RS05285	GAS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177332	SLC-391	Inhibitor	/	Unkown
HY-RS16715	Gas6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23150	Gas6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992231	Anti-GAS6 Antibody (KM5321)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GAS6	MGD	MGI:95660
Bos taurus	GAS6	VGNC	VGNC:29261
Macaca mulatta	GAS6	VGNC	VGNC:72885
Canis familiaris	GAS6	VGNC	VGNC:41118
Felis catus	GAS6	VGNC	VGNC:62469
Rattus norvegicus	GAS6	RGD	RGD:61913
Others	GAS6	NCBI