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58986

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4

Inhibitors & Agonists

1

Peptides

5

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10936
    S 18986

    		iGluR Neurological Disease
    S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests .
    S 18986
  • HY-P1223
    Exendin-3/4 (59-86)

    		GCGR Metabolic Disease
    Exendin-3/4 (59-86) is a Exendin-4 peptide derivative.
    Exendin-3/4 (59-86)
  • HY-117368
    AL-8417

    (2R)-AL-5898

    		 COX Inflammation/Immunology
    AL-8417 ((2R)-AL-5898) is a potent inhibitor of Cyclooxygenase (COX), with IC50 of 120 μM, that plays an important role in inflammatory response .
    AL-8417
  • HY-180320
    Lu AF58786

    		LRRK2 Neurological Disease
    Lu AF58786 is a potent and selective LRRK2 inhibitor with an IC50 of 12 nM. Lu AF58786 also exhibits inhibition activity against LRRK2 G2019S and LRRK2 A2016T with IC50s of 19 and 93 nM. Lu AF58786 inhibits phosphorylation of LRRK2, Rab10 and Rab12 in human peripheral blood mononuclear cells. Lu AF58786 can be used for parkinson’s disease research .
    Lu AF58786

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