PPCDC - phosphopantothenoylcysteine decarboxylase Gene

Homo sapiens

Also known as coaC; MDS018; PPC-DC

Gene ID: 60490 | Gene type: protein coding

About PPCDC

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,023,590-75,050,726 (from NCBI)

This gene has 11 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 1.6), appendix (RPKM 1.5) and 25 other tissues.

Summary

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

PPCDC Products(6)

mRNA	Protein	Name
NM_001301101.2	NP_001288030.1	phosphopantothenoylcysteine decarboxylase isoform b
NM_001301102.2	NP_001288031.1	phosphopantothenoylcysteine decarboxylase isoform c
NM_001301103.2	NP_001288032.1	phosphopantothenoylcysteine decarboxylase isoform d
NM_001301104.2	NP_001288033.1	phosphopantothenoylcysteine decarboxylase isoform e
NM_001301105.2	NP_001288034.1	phosphopantothenoylcysteine decarboxylase isoform e
NM_021823.5	NP_068595.3	phosphopantothenoylcysteine decarboxylase isoform a

PPCDC Protein Structure

Flavoprotein

0
100
204 a.a.

Protein Preferred Names

Protein Names

phosphopantothenoylcysteine decarboxylase

Recombinant PPCDC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71222	PPC-DC Protein, Human (His)	Q96CD2 (M1-S204)	≥95%
HY-P71222A	PPC-DC Protein, Human (His, solution)	Q96CD2 (M1-S204)	≥95%

Related Diseases

Diseases

Alias

Cecum Carcinoma

Cecum Cancer	Caecum Carcinoma
Carcinoma Of Cecum	Cecal Cancer
Malignant Neoplasm Of Caecum	Malignant Tumor Of The Cecum

Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum

Thyroid Dyshormonogenesis 6

TDH6	Genetic Defect In Thyroid Hormonogenesis 6
Thyroid Hormonogenesis, Genetic Defect In, 6	Hypothyroidism, Congenital, Due To Dyshormonogenesis, 6
Chdh6	Congenital Hypothyroidism Due To Dyshormonogenesis Type 6

Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Neurodegeneration With Brain Iron Accumulation 1

Pantothenate Kinase-Associated Neurodegeneration	Pkan
NBIA1	Hallervorden-Spatz Disease
Hallervorden-Spatz Syndrome	Pigmentary Pallidal Degeneration
Neuroaxonal Dystrophy, Late Infantile	Neurodegeneration With Brain Iron Accumulation Type 1
Classic Pantothenate Kinase-Associated Neurodegeneration	Pkan Neuroaxonal Dystrophy, Juvenile-Onset
Brain Iron Accumulation Type I Syndrome	Nbia
Neurodegeneration With Brain Iron Accumulation	Nbia1, Classic Form
Neurodegeneration With Brain Iron Accumulation Type 1, Classic Form	Pkan, Classic Form
Atypical Pantothenate Kinase-Associated Neurodegeneration	Nbia1, Atypical Form
Neurodegeneration With Brain Iron Accumulation Type 1, Atypical Form	Pkan, Atypical Form
Hss	Pkan Neuroaxonal Dystrophy Juvenile-Onset
Neurodegeneration, With Brain Iron Accumulation, Type 1

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10934	PPCDC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPCDC	VGNC	VGNC:64306
Rattus norvegicus	PPCDC	RGD	RGD:1306267
Mus musculus	PPCDC	MGD	MGI:1914062
Bos taurus	PPCDC	VGNC	VGNC:33188
Macaca mulatta	PPCDC	VGNC	VGNC:76124
Canis familiaris	PPCDC	VGNC	VGNC:44840
Others	PPCDC	NCBI

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