Nmu - neuromedin U Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63887

Summary

Enables type 1 neuromedin U receptor binding activity and type 2 neuromedin U receptor binding activity. Involved in several processes, including energy homeostasis; negative regulation of digestive system process; and positive regulation of cell communication. Acts upstream of or within neuropeptide signaling pathway. Located in terminal bouton. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMU (neuromedin U). [provided by Alliance of Genome Resources, Apr 2022]

Nmu Products (1)

mRNA Protein Name
NM_022239.3 NP_071575.1 neuromedin-U precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuromedin U receptor binding IDA
IDA: Inferred from direct assay
15635449 RGD
enables type 1 neuromedin U receptor binding IDA
IDA: Inferred from direct assay
28874765 RGD
enables type 2 neuromedin U receptor binding IDA
IDA: Inferred from direct assay
28874765 RGD
Biological Process GO Annotation Evidence References Source
involved in eating behavior IDA
IDA: Inferred from direct assay
10894543 RGD
involved in energy homeostasis IDA
IDA: Inferred from direct assay
10894543 RGD
involved in gastric acid secretion IMP
IMP: Inferred from mutant phenotype
12584108 RGD
involved in negative regulation of eating behavior IDA
IDA: Inferred from direct assay
10894543 RGD
involved in negative regulation of feeding behavior IDA
IDA: Inferred from direct assay
20233222 RGD
involved in negative regulation of gastric acid secretion IDA
IDA: Inferred from direct assay
12584108 RGD
involved in negative regulation of gastric emptying IDA
IDA: Inferred from direct assay
12584108 RGD
acts upstream of or within neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
15635449 RGD
involved in photoperiodism IEP
IEP: Inferred from expression pattern
17726140 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
28874765 RGD
involved in positive regulation of heart rate IDA
IDA: Inferred from direct assay
11853869 RGD
involved in positive regulation of heat generation IDA
IDA: Inferred from direct assay
11027662 RGD
involved in positive regulation of hormone secretion IMP
IMP: Inferred from mutant phenotype
17726140 RGD
involved in positive regulation of prolactin secretion IDA
IDA: Inferred from direct assay
28874765 RGD
involved in positive regulation of sensory perception of pain IDA
IDA: Inferred from direct assay
12890516 RGD
involved in positive regulation of smooth muscle contraction IDA
IDA: Inferred from direct assay
3178840 RGD
involved in positive regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
16474416 RGD
involved in positive regulation of stomach fundus smooth muscle contraction IDA
IDA: Inferred from direct assay
2055247 RGD
involved in positive regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
15297576 RGD
involved in positive regulation of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
11853869 RGD
involved in regulation of circadian sleep/wake cycle, sleep IDA
IDA: Inferred from direct assay
20233222 RGD
involved in regulation of grooming behavior IDA
IDA: Inferred from direct assay
12399416 RGD
Cellular Component GO Annotation Evidence References Source
located in terminal bouton IDA
IDA: Inferred from direct assay
15297576 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuromedin-U

  • neuromedin U precursor-related peptide/neuromedin U preproprotein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-34758 N-Nitroso-N-methylurea 99.74% Unkown
HY-P1238A Neuromedin U, rat TFA 99.90% Unkown
HY-N6629 3'-Methoxyflavonol 99.92% Unkown
HY-P1238 Neuromedin U, rat / Unkown
HY-P5084 Neuromedin S (human) / Unkown
HY-RS09391 NMU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W717139 N-Nitroso-N-methylurea-d5 / Unkown
HY-RS17526 Nmu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23983 Nmu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990173 Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) 99.406% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nmu NCBI NCBI:10874