Dusp10 - dual specificity phosphatase 10 Gene

Also Known as MKP5; MKP-5; 2610306G15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 63953

Summary

Enables MAP kinase Phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of epithelial cell migration; and negative regulation of epithelium regeneration. Acts upstream of or within several processes, including negative regulation of protein kinase activity; negative regulation of respiratory burst involved in inflammatory response; and oligodendrocyte differentiation. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human DUSP10 (dual specificity Phosphatase 10). [provided by Alliance of Genome Resources, Apr 2022]

Dusp10 Products (1)

mRNA Protein Name
NM_022019.6 NP_071302.2 dual specificity protein phosphatase 10

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables MAP kinase phosphatase activity IDA
IDA: Inferred from direct assay
25772234 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
25772234 MGI
acts upstream of or within negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
15306813 MGI
acts upstream of or within negative regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
15306813 MGI
involved in negative regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
25772234 MGI
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
25772234 MGI
involved in negative regulation of epithelium regeneration IDA
IDA: Inferred from direct assay
25772234 MGI
acts upstream of or within negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
23977283 MGI
acts upstream of or within negative regulation of respiratory burst involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
19696743 MGI
acts upstream of or within negative regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
19696743 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19139271 MGI
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
25772234 MGI
acts upstream of or within regulation of adaptive immune response IMP
IMP: Inferred from mutant phenotype
15306813 MGI
acts upstream of or within regulation of brown fat cell differentiation IDA
IDA: Inferred from direct assay
23874687 MGI
acts upstream of or within regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
15306813 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19696743 MGI
acts upstream of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
19696743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 10

  • MAP kinase phosphatase 5

  • mitogen-activated protein kinase phosphatase 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04051 DUSP10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27638 Dusp10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21119 Dusp10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp10 NCBI NCBI:11221