Ccn2 - cellular communication network factor 2 Gene

Also Known as Ctgf; CTGRP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64032

Summary

Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of Collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cis-Golgi network; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; primary biliary cholangitis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccn2 Products (1)

mRNA Protein Name
NM_022266.2 NP_071602.1 CCN family member 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibronectin binding IDA
IDA: Inferred from direct assay
18167060 RGD
enables growth factor activity IDA
IDA: Inferred from direct assay
10026205 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane import into cytosol IMP
IMP: Inferred from mutant phenotype
19707545 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
19625611 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19625611 RGD
involved in cellular response to interleukin-13 IEP
IEP: Inferred from expression pattern
21804025 RGD
involved in extracellular matrix constituent secretion IMP
IMP: Inferred from mutant phenotype
18613219 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12193543 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
19361631 RGD
involved in microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
20858895 RGD
involved in positive regulation of G0 to G1 transition IMP
IMP: Inferred from mutant phenotype
18613219 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19625611 RGD
involved in positive regulation of cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
19707545 RGD
involved in positive regulation of cell activation IMP
IMP: Inferred from mutant phenotype
18613219 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19570811 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
19570811 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
19625611 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19570811 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19707545 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17250813 RGD
involved in response to anoxia IEP
IEP: Inferred from expression pattern
18929865 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19509476 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
19656915 RGD
involved in response to mineralocorticoid IEP
IEP: Inferred from expression pattern
19521108 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19558898 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
19667256 RGD
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
19359517 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
19570811 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19359517 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CCN family member 2

  • connective tissue growth factor

  • connective tissue growth-related protein

Recombinant Ccn2 Proteins

Cat. No. Product Name Accession Purity
HY-P79369 CCN2/CTGF Protein, Rat (HEK293) Q9R1E9 (Q25-A347) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-167201 2ccPA Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5314 OK2 Inhibitor 99.13% Unkown
HY-RS02111 CCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181537 PROTAC TEAD1/IAP degrader-2 / Unkown
HY-184179 TEAD degrader-1 Degrader / Unkown
HY-184366 2C-CN hydrochloride Agonist / Unkown
HY-RS17160 Ccn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23610 Ccn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccn2 NCBI NCBI:1490