Qdpr - quinoid dihydropteridine reductase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64192

Summary

Enables 6,7-dihydropteridine reductase activity; identical protein binding activity; and nucleotide binding activity. Involved in several processes, including L-phenylalanine catabolic process; response to glucagon; and tetrahydrobiopterin biosynthetic process. Located in cytosol and neuron projection. Biomarker of hypertension and status epilepticus. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Apr 2022]

Qdpr Products (1)

mRNA Protein Name
NM_022390.2 NP_071785.1 dihydropteridine reductase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 6,7-dihydropteridine reductase activity IDA
IDA: Inferred from direct assay
660556 RGD
enables 6,7-dihydropteridine reductase activity IMP
IMP: Inferred from mutant phenotype
1898002 RGD
enables NADH binding IPI
IPI: Inferred from physical interaction
8631945 RGD
enables NADPH binding IMP
IMP: Inferred from mutant phenotype
1639779 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
1631094 RGD
Biological Process GO Annotation Evidence References Source
involved in L-phenylalanine catabolic process IEP
IEP: Inferred from expression pattern
4155291 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
2484967 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
710385 RGD
involved in response to aluminum ion IEP
IEP: Inferred from expression pattern
3477172 RGD
involved in response to glucagon IEP
IEP: Inferred from expression pattern
4155291 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
3815851 RGD
involved in tetrahydrobiopterin biosynthetic process IDA
IDA: Inferred from direct assay
660556 RGD
involved in tetrahydrobiopterin biosynthetic process IMP
IMP: Inferred from mutant phenotype
1898002 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydropteridine reductase

  • HDHPR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W320239 QDPR-IN-1 99.28% Unkown
HY-RS11499 QDPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19941 Qdpr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26443 Qdpr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Qdpr NCBI NCBI:5860