Casp2 - caspase 2 Gene

Rattus norvegicus

Gene ID: 64314 | Gene type: protein coding

About Casp2

Primary_assembly 4: 71,149,669-71,167,379 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 215 orthologues, 12 paralogues and is associated with 6 phenotypes. Biased expression in Thymus (RPKM 234.6), Spleen (RPKM 136.1) and 9 other tissues.

Summary

Predicted to enable cysteine-type endopeptidase activity involved in apoptotic process; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including aging; animal organ development; and positive regulation of neuron apoptotic process. Located in membrane and mitochondrion. Biomarker of status epilepticus. Orthologous to human CASP2 (Caspase 2). [provided by Alliance of Genome Resources, Apr 2022]

Casp2 Products(1)

mRNA	Protein	Name
NM_022522.3	NP_071967.2	caspase-2

Casp2 Protein Structure

CARD_CASP2

CASc

0
100
200
300
400
470 a.a.

Protein Preferred Names

Protein Names

caspase-2

CASP-2	ICH-1 protease
protease ICH-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-P0227	SHU 9119	99.95%	Unkown
HY-RS01949	CASP2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS01950	Casp2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS01951	Casp2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp2	NCBI	NCBI:835

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