Icos - inducible T-cell co-stimulator Gene

Also Known as Ailim

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64545

Summary

Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2022]

Icos Products (1)

mRNA Protein Name
NM_022610.2 NP_072132.1 inducible T-cell costimulator precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in T cell costimulation IDA
IDA: Inferred from direct assay
11006126 RGD
involved in T cell tolerance induction IMP
IMP: Inferred from mutant phenotype
16220623 RGD
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
10607749 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inducible T-cell costimulator

  • activation-inducible lymphocyte immunomediatory molecule

Recombinant Icos Proteins

Cat. No. Product Name Accession Purity
HY-P74868 ICOS Protein, Rat (HEK293, Fc) Q9R1T7-1 (E21-L142) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99363 Feladilimab 99.255% Phase 3
HY-P99414 Prezalumab Inhibitor 99.41% Phase 2
HY-P99420 Acazicolcept Antagonist 99.27% Phase 2
HY-P99474 Bertilimumab Inhibitor 97.01% Phase 2
HY-P99431 KY-1044 99.51% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150743 ODN 2395 Agonist 98.39% Unkown
HY-159692 AZD8701 Inhibitor 96.61% Unkown
HY-W011267 (Z)-Methyl icos-11-enoate 98.02% Unkown
HY-162810 ICOS-IN-1 / Unkown
HY-RS06520 ICOS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011267R (Z)-Methyl icos-11-enoate (Standard) / Unkown
HY-166209 Ethyl 8(Z)-eicosenoate / Unkown
HY-184441 CD28-IN-4 Inhibitor / Unkown
HY-RS16819 Icos Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23260 Icos Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990236 Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) Inhibitor 98.81% Unkown
HY-P990237 Anti-Mouse ICOS Antibody (7E.17G9) Inhibitor 98% Unkown
HY-P99679 Izuralimab Inhibitor 99.97% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Icos NCBI NCBI:29851