TUT1 - terminal uridylyl transferase 1, U6 snRNA-specific Gene

Also Known as PAPD2; RBM21; TENT1; URLC6; TUTase; STARPAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64852

About TUT1

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,575,052-62,591,523 (from NCBI)

This gene has 7 transcripts (splice variants), 195 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 10.1), spleen (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]

TUT1 Products (2)

mRNA	Protein	Name
NM_001367906.1	NP_001354835.1	speckle targeted PIP5K1A-regulated poly(A) polymerase isoform 2
NM_022830.3	NP_073741.3	speckle targeted PIP5K1A-regulated poly(A) polymerase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	18288197	GOA
enables RNA uridylyltransferase activity	IDA IDA: Inferred from direct assay	16790842	GOA
enables U6 snRNA binding	IDA IDA: Inferred from direct assay	28589955	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	18305108	GOA
enables enzyme-substrate adaptor activity	IDA IDA: Inferred from direct assay	21102410	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	21102410	GOA
enables poly(A) RNA polymerase activity	IDA IDA: Inferred from direct assay	18288197	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18288197	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in U6 snRNA 3'-end processing	IDA IDA: Inferred from direct assay	28589955	GOA
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IDA IDA: Inferred from direct assay	21102410	GOA
NOT involved in histone mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	18172165	GOA
involved in mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	18288197	GOA
involved in snRNA processing	IMP IMP: Inferred from mutant phenotype	16790842	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	18305108	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	18288197	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16790842	GOA
is active in nucleoplasm	IDA IDA: Inferred from direct assay	32839293	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUT1 Protein Structure

zf-met

PAP_assoc

0
200
400
600
800
874 a.a.

Protein Preferred Names	Protein Names
speckle targeted PIP5K1A-regulated poly(A) polymerase	PAP-associated domain-containing 2

TUT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TUT1	Q9H6E5	PIP5K1A	Homo sapiens	Q99755-1	Y2H	18288197
Intra	TUT1	Q9H6E5	PIP5K1A	Homo sapiens	Q99755-1	Pull Down	18288197
Intra	TUT1	Q9H6E5	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	TUT1	Q9H6E5	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	TUT1	Q9H6E5	PIP5K1A	Homo sapiens	Q99755	Anti Bait CoIP	18288197
Intra	TUT1	Q9H6E5	PIP5K1A	Homo sapiens	Q99755	Anti Tag CoIP	18288197

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Renal Wilms' Tumor	Nonanaplastic Renal Wilm'S Tumor Nonanaplastic Renal Wilm'S Tumour Nonanaplastic Renal Wilms Tumor Renal Wilms' Tumour
Trichothiodystrophy 6, Nonphotosensitive	TTD6 Nonphotosensitive Trichothiodystrophy 6 Trichothiodystrophy 6, Non-Photosensitive
Nonphotosensitive Trichothiodystrophy	Trichothiodystrophy Nonphotosensitive Amish Brittle Hair Brain Syndrome
Trichothiodystrophy 1, Photosensitive	TTD1 Tay Syndrome Trichothiodystrophy With Congenital Ichthyosis Photosensitive Trichothiodystrophy Ibids Syndrome Ttdp Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation Ichthyosis, Congenital, With Trichothiodystrophy Pibids Syndrome Photosensitive Trichothiodystrophy 1 Trichothiodystrophy, Photosensitive Sulfur-Deficient Brittle Hair Syndrome Ttd-P Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature Trichothiodystrophy Photosensitive Trichothiodystrophy, Type 1 Tricho-Thiodystrophy Disorder Trichothiodystrophy Syndromes Amish Brittle Hair Brain Syndrome
Perlman Syndrome	Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor PRLMNS Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome Renal Hamartomas Nephroblastomatosis And Fetal Gigantism Nephroblastoma Fetal Macrosomia
Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio Type PN Clericuzio Type Poikiloderma With Neutropenia Poikiloderma With Neutropenia, Clericuzio-Type Clericuzio-Type Poikiloderma With Neutropenia Poikiloderma With Neutropenia Clericuzio Type Immune-Deficient Poikiloderma Clericuzio-Type Poikiloderma Neutropenia Syndrome Poikiloderma With Neutropenia Clericuzio-Type Poikiloderma, With Neutropenia
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15276	TUT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TUT1	VGNC	VGNC:101424
Felis catus	TUT1	VGNC	VGNC:104347
Rattus norvegicus	TUT1	RGD	RGD:1561043
Mus musculus	TUT1	MGD	MGI:1917294
Canis familiaris	TUT1	VGNC	VGNC:52059