SIPA1 - signal-induced proliferation-associated 1 Gene

Also Known as SPA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6494

About SIPA1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,638,101-65,650,912 (from NCBI)

This gene has 10 transcripts (splice variants), 175 orthologues and 6 paralogues. Broad expression in spleen (RPKM 30.1), lymph node (RPKM 17.9) and 24 other tissues.

Summary

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or Other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

SIPA1 Products (2)

mRNA Protein Name
NM_006747.4 NP_006738.3 signal-induced proliferation-associated protein 1
NM_153253.30 NP_694985.29 signal-induced proliferation-associated protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity EXP
EXP: Inferred from Experiment
16076873 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIPA1 Protein Structure

Rap_GAP

Rap_GAP: Rap/ran-GAP (350 - 539)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (688 - 758)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1042 a.a.
Protein Preferred Names Protein Names

signal-induced proliferation-associated protein 1

  • GTPase-activating protein Spa-1

SIPA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIPA1 Q96FS4 CDKN1A Homo sapiens P38936
Anti Tag CoIP
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Juvenile Myelomonocytic Leukemia

  • Leukemia, Juvenile Myelomonocytic

  • JMML

  • Leukemia, Juvenile Myelomonocytic, Somatic

  • Juvenile Chronic Myelomonocytic Leukemia

  • Juvenile Chronic Myelogenous Leukemia

  • Leukemia, Myelomonocytic, Juvenile

  • Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myeloproliferative Neoplasm

  • Myeloproliferative Disorder

  • Chronic Myeloproliferative Disease

  • Myeloproliferative Neoplasms

  • Chronic Myeloproliferative Disorder

  • Cmpd

  • Cmpd, U

  • Chronic Myeloproliferative Disorders

  • Mpd

  • Mpn

  • Myeloproliferative Disorders

  • Myeloproliferative Disease

  • Campomelic Dysplasia
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12928 SIPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12929 SIPA1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12930 SIPA1L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12931 SIPA1L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIPA1 MGD MGI:107576
Canis familiaris SIPA1 VGNC VGNC:46179
Macaca mulatta SIPA1 VGNC VGNC:77218
Bos taurus SIPA1 VGNC VGNC:34627
Felis catus SIPA1 VGNC VGNC:65152
Rattus norvegicus SIPA1 RGD RGD:1303184
Others SIPA1 NCBI