Sdha - succinate dehydrogenase complex, subunit A, flavoprotein (Fp) Gene

Also Known as FP; SDH2; SDHF; 4921513A11; 1500032O14Rik; 2310034D06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66945

Summary

Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and Succinate Dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone; nervous system development; and succinate metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (Succinate Dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Sdha Products (1)

mRNA Protein Name
NM_023281.1 NP_075770.1 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
26644517 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16120479 MGI
part of respiratory chain complex II (succinate dehydrogenase) IDA
IDA: Inferred from direct assay
16120479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

  • flavoprotein subunit of complex II

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12590 SDHA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131453 Mitochondrial respiration-IN-1 Inhibitor / Unkown
HY-180786 DdBIC / Unkown
HY-RS18790 Sdha Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25279 Sdha Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sdha NCBI NCBI:6389