Jam2 - junction adhesion molecule 2 Gene

Also Known as JAM-2; JAM-B; Jcam2; VE-JAM; 1110002N23Rik; 2410030G21Rik; 2410167M24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67374

Summary

Predicted to enable Integrin binding activity. Involved in several processes, including hematopoietic stem cell migration to bone marrow; leukocyte tethering or rolling; and negative regulation of myelination. Acts upstream of or within negative regulation of cell adhesion. Located in cell surface; somatodendritic compartment; and tight junction. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human JAM2 (junctional adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]

Jam2 Products (1)

mRNA Protein Name
NM_023844.5 NP_076333.3 junctional adhesion molecule B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16093349 MGI
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24357068 MGI
involved in cellular extravasation IDA
IDA: Inferred from direct assay
12239159 MGI
involved in hematopoietic stem cell migration to bone marrow IMP
IMP: Inferred from mutant phenotype
24357068 MGI
involved in leukocyte tethering or rolling IDA
IDA: Inferred from direct assay
19740376 MGI
acts upstream of or within negative regulation of cell adhesion IGI
IGI: Inferred from genetic interaction
16093349 MGI
involved in negative regulation of myelination IMP
IMP: Inferred from mutant phenotype
27499083 MGI
involved in positive regulation of lymphocyte migration IMP
IMP: Inferred from mutant phenotype
12239159 MGI
involved in spermatid development IDA
IDA: Inferred from direct assay
15372036 MGI
Cellular Component GO Annotation Evidence References Source
NOT located in axon IDA
IDA: Inferred from direct assay
27499083 MGI
located in cell surface IDA
IDA: Inferred from direct assay
12239159 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
27499083 MGI
located in tight junction IDA
IDA: Inferred from direct assay
15372036 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junctional adhesion molecule B

  • junction adhesion molecule B

  • junction cell adhesion molecule 2

  • junctional adhesion molecule 2

  • vascular endothelial junction-associated molecule

Recombinant Jam2 Proteins

Cat. No. Product Name Accession Purity
HY-P73259 JAM-B/CD322 Protein, Mouse (HEK293, Fc) Q9JI59 (F29-N236) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P73260 JAM-B/CD322 Protein, Mouse (HEK293, His) Q9JI59 (F29-N236) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07027 JAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07028 JAM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18768 Jam2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25256 Jam2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jam2 NCBI NCBI:58494