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STATH - statherin Gene

Also Known as STR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6779

About STATH

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,995,966-70,002,570 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 13 orthologues and 2 paralogues. Restricted expression toward salivary gland (RPKM 34203.8).

Summary

Predicted to be involved in ossification. [provided by Alliance of Genome Resources, Apr 2022]

STATH Products (2)

mRNA	Protein	Name
NM_001009181.2	NP_001009181.1	statherin isoform b precursor
NM_003154.3	NP_003145.1	statherin isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	1718282	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STATH Protein Structure

Statherin

0
62 a.a.

Protein Preferred Names	Protein Names
statherin

STATH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STATH	P02808	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	STATH	P02808	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	STATH	P02808	TFAM	Homo sapiens	Q00059	Validated Y2H	32296183
Intra	STATH	P02808	TFAM	Homo sapiens	Q00059	Y2H Array	32296183
Intra	STATH	P02808	TFAM	Homo sapiens	Q00059	Y2H Prey Pooling	32296183
Intra	STATH	P02808	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	STATH	P02808	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	STATH	P02808	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	STATH	P02808	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	STATH	P02808	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
Intra	STATH	P02808	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	STATH	P02808	DERL3	Homo sapiens	Q96Q80	Y2H Prey Pooling	32296183
Intra	STATH	P02808	DERL3	Homo sapiens	Q96Q80	Validated Y2H	32296183
Intra	STATH	P02808	DERL3	Homo sapiens	Q96Q80	Y2H Array	32296183
Intra	STATH	P02808	FIMP	Homo sapiens	Q96LL3	Validated Y2H	32296183
Intra	STATH	P02808	FIMP	Homo sapiens	Q96LL3	Y2H Array	32296183
Intra	STATH	P02808	FIMP	Homo sapiens	Q96LL3	Y2H Prey Pooling	32296183
Intra	STATH	P02808	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	STATH	P02808	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	STATH	P02808	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	STATH	P02808	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	STATH	P02808	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	STATH	P02808	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	STATH	P02808	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	STATH	P02808	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	STATH	P02808	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	STATH	P02808	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	STATH	P02808	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	STATH	P02808	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	STATH	P02808	FCRL3	Homo sapiens	Q96P31-6	Y2H Prey Pooling	32296183
Intra	STATH	P02808	FCRL3	Homo sapiens	Q96P31-6	Validated Y2H	32296183
Intra	STATH	P02808	FCRL3	Homo sapiens	Q96P31-6	Y2H Array	32296183
Intra	STATH	P02808	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	STATH	P02808	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	STATH	P02808	SPNS3	Homo sapiens	Q6ZMD2-2	Y2H Prey Pooling	32296183
Intra	STATH	P02808	SPNS3	Homo sapiens	Q6ZMD2-2	Validated Y2H	32296183
Intra	STATH	P02808	SPNS3	Homo sapiens	Q6ZMD2-2	Y2H Array	32296183
Intra	STATH	P02808	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	STATH	P02808	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	STATH	P02808	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	STATH	P02808	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	STATH	P02808	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	STATH	P02808	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	STATH	P02808	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	STATH	P02808	MFSD5	Homo sapiens	Q6N075	Y2H Array	32296183
Intra	STATH	P02808	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	STATH	P02808	MFSD5	Homo sapiens	Q6N075	Y2H Prey Pooling	32296183
Intra	STATH	P02808	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	STATH	P02808	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	STATH	P02808	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	STATH	P02808	MRM1	Homo sapiens	Q6IN84	Validated Y2H	32296183
Intra	STATH	P02808	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	STATH	P02808	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	STATH	P02808	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	STATH	P02808	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	STATH	P02808	MUC7	Homo sapiens	Q8TAX7	Far-WB	16203048
Intra	STATH	P02808	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	STATH	P02808	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	STATH	P02808	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	STATH	P02808	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	STATH	P02808	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	STATH	P02808	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STATH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76665	Statherin Protein, Human (HEK293, Fc)	P02808-1 (M1-F62)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Enamel Erosion
Sialolithiasis	Sialolith Stone Of Salivary Gland Or Duct Salivary Gland Calculi Salivary Gland Stone Calculus Of Salivary Gland Or Duct Calculus Of Salivary Gland Salivary Calculus Salivary Gland Calculus Salivary Stone Salivary Duct Calculi Sialodocholithiasis
Acute Apical Periodontitis	Acute Apical Periodontitis Of Pulpal Origin Acute Apical Periodontitis Nos Aap - [Acute Apical Periodontitis]
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Tooth Erosion	Generalized Erosion Localized Erosion Generalized Erosions Erosion, Localized
Enamel Caries	Primary Dental Caries Dental Caries Limited To Enamel Simple Dental Cavity
Root Caries	Cementum Caries Dental Caries Of Root Surface
Angular Cheilitis	Cheilosis Angular Cheilosis Angular Stomatitis Commissural Cheilitis
Fissured Tongue	Furrowed Tongue Plicated Tongue Tongue, Fissured Congenital Fissure Of Tongue Congenital Plicated Tongue Fissure Of Tongue Fissure Of Tongue, Congenital Geographic Tongue And Fissured Tongue Lingua Plicata Scrotal Tongue
Denture Stomatitis	Stomatitis, Denture Denture Sore Mouth
Li-Fraumeni Syndrome 1	Lfs1
Teeth Hard Tissue Disease
Autosomal Recessive Hypophosphatemic Rickets	Arhr Hypophosphatemic Rickets, Autosomal Recessive Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
Gingival Disease	Gingival Diseases Gum Disease Gingival Disorder Gingivitis And Periodontal Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13899	STATH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24467	Stath Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STATH	RGD	RGD:1589974
Macaca fascicularis	STATH	NCBI
Mus musculus	STATH	NCBI
Macaca mulatta	STATH	NCBI
Others	STATH	NCBI