STYX - serine/threonine/tyrosine interacting protein Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6815

About STYX

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,730,166-52,774,989 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues.

Summary

The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]

STYX Products (2)

mRNA Protein Name
NM_001130701.2 NP_001124173.1 serine/threonine/tyrosine-interacting protein
NM_145251.4 NP_660294.1 serine/threonine/tyrosine-interacting protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables F-box domain binding IMP
IMP: Inferred from mutant phenotype
28007894 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23847209 GOA
enables pseudophosphatase activity IMP
IMP: Inferred from mutant phenotype
28007894 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IMP
IMP: Inferred from mutant phenotype
28007894 GOA
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
28007894 GOA
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23847209 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23847209 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23847209 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STYX Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (36 - 172)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

serine/threonine/tyrosine-interacting protein

  • inactive tyrosine-protein phosphatase STYX

STYX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0
Anti Bait CoIP
28007894
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0
Peptide Array
28007894
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0
Anti Tag CoIP
28007894
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0
Anti Tag CoIP
27880917
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0
Pull Down
28007894
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0-1
Anti Tag CoIP
28007894
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0-1
BiFC
28007894
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0-1
Pull Down
28007894
Intra
STYX Q8WUJ0 FBXW7 Homo sapiens Q969H0-1
Confocal
28007894
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13997 STYX Human Pre-designed siRNA Set A Pre-designed Set / Unkown