Eif4a3 - eukaryotic translation initiation factor 4A3 Gene

Also Known as eIF4A-III

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 688288

Summary

Enables RNA binding activity; ribonucleoprotein complex binding activity; and translation regulator activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to selenite ion; and regulation of translation. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Part of ribonucleoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Apr 2022]

Eif4a3 Products (1)

mRNA	Protein	Name
NM_001100158.2	NP_001093628.1	eukaryotic initiation factor 4A-III

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	21685449	RGD
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	17632064	RGD
enables selenocysteine insertion sequence binding	IDA IDA: Inferred from direct assay	21685449	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in associative learning	IEP IEP: Inferred from expression pattern	22982623	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: Inferred from expression pattern	17632064	RGD
involved in cellular response to selenite ion	IEP IEP: Inferred from expression pattern	19716792	RGD
involved in exploration behavior	IEP IEP: Inferred from expression pattern	22982623	RGD
involved in negative regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17632064	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17632064	RGD
involved in negative regulation of selenocysteine incorporation	IDA IDA: Inferred from direct assay	19716792	RGD
involved in regulation of translation at postsynapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	17632064	RGD
involved in regulation of translation at postsynapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	17632064	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17632064	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	17632064	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17632064	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17632064	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17632064	RGD
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17632064	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
eukaryotic initiation factor 4A-III	ATP-dependent RNA helicase DDX48 ATP-dependent RNA helicase eIF4A-3 DEAD box protein 48 eIF-4A-III

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101513	eIF4A3-IN-1	Inhibitor	99.96%	Unkown
HY-101785	eIF4A3-IN-2	Inhibitor	99.70%	Unkown
HY-33838	eIF4A3-IN-8	Control	99.93%	Unkown
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	Unkown
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	Unkown
HY-43913	(R)-eIF4A3-IN-2		95.0%	Unkown
HY-139872	eIF4A3-IN-4	Inhibitor	99.8%	Unkown
HY-145309	eIF4E-IN-3	Inhibitor	/	Unkown
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	Unkown
HY-148444	eIF4A3-IN-10	Inhibitor	97.87%	Unkown
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	Unkown
HY-148447	eIF4A-IN-3	Inhibitor	99.92%	Unkown
HY-148448	eIF4A3-IN-14	Inhibitor	99.81%	Unkown
HY-148449	eIF4A3-IN-15	Inhibitor	/	Unkown
HY-148450	eIF4A3-IN-16	Inhibitor	99.96%	Unkown
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	Unkown
HY-145359	eIF4A3-IN-5	Inhibitor	/	Unkown
HY-145360	eIF4A3-IN-6	Inhibitor	/	Unkown
HY-145361	eIF4A3-IN-7	Inhibitor	/	Unkown
HY-RS04272	EIF4A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04276	EIF4E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04279	EIF4EBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04283	EIF4G3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17850	Eif4a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24318	Eif4a3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif4a3	NCBI	NCBI:9775