Cdk13 - cyclin-dependent kinase 13 Gene

Also Known as Cdc2l5; 2310015O17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69562

About Cdk13

Chromosome 13: 17,884,900-17,979,682 reverse strand.GRCm39:CM001006.3

This gene has 7 transcripts (splice variants), 207 orthologues, 25 paralogues and is associated with 40 phenotypes. Ubiquitous expression in ovary adult (RPKM 9.), thymus adult (RPKM 8.) and 28 other tissues.

Summary

Enables cyclin binding activity and protein kinase binding activity. Involved in alternative mRNA splicing, via spliceosome. Acts upstream of or within negative regulation of stem cell differentiation. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; future brain; primitive streak; trophectoderm; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder. Orthologous to human CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Apr 2022]

Cdk13 Products (2)

mRNA Protein Name
NM_001081058.2 NP_001074527.1 cyclin-dependent kinase 13 isoform 1
NM_027118.1 NP_081394.1 cyclin-dependent kinase 13 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
17261272 MGI
enables protein kinase binding IDA
IDA: Inferred from direct assay
22547058 MGI
Biological Process GO Annotation Evidence References Source
involved in alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
17261272 MGI
acts upstream of or within negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22547058 MGI
Cellular Component GO Annotation Evidence References Source
part of nuclear cyclin-dependent protein kinase holoenzyme complex IDA
IDA: Inferred from direct assay
17261272 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk13 Protein Structure

STKc_CDK12

STKc_CDK12: cd07864 (696 - 997)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1451 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 13

  • CDC2-related protein kinase 5

  • cell division cycle 2-like 5 (cholinesterase-related cell division controller)

  • cell division cycle 2-like protein kinase 5

  • cell division protein kinase 13

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 99.06% Unkown
HY-168555 YJ1206 Degrader 97.26% Unkown
HY-153244 MFH290 Inhibitor 98.29% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 99.12% Unkown
HY-168162 ZLC491 Degrader 98.51% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.88% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader 98.01% Unkown
HY-173059 CDK12/13-IN-3 Inhibitor 99.14% Unkown
HY-168556 YJ9069 Degrader / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-158170 CDK7-IN-28 Inhibitor / Unkown
HY-181035 DN1679 Degrader / Unkown
HY-173273 YJZ5118 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-48507 CDK12/13 ligand 4 Ligand / Unkown
HY-168658 CDK12/13 ligand 2 Degrader / Unkown
HY-181036 CDK12/13 ligand 3 Ligand / Unkown
HY-181405 SR-5037 Inhibitor 99.58% Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-168163 CDK12/13 ligand 1 Degrader / Unkown
HY-173042 CDK12/13-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk13 NCBI NCBI:8621