TEP1 - telomerase associated protein 1 Gene

Also Known as TP1; TLP1; p240; TROVE1; VAULT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7011

About TEP1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,365,667-20,413,501 (from NCBI)

This gene has 11 transcripts (splice variants), 106 orthologues and 26 paralogues. Ubiquitous expression in duodenum (RPKM 11.6), small intestine (RPKM 7.0) and 24 other tissues.

Summary

This gene product is a component of the ribonucleoprotein complex responsible for Telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

TEP1 Products (2)

mRNA Protein Name
NM_001319035.2 NP_001305964.1 telomerase protein component 1 isoform 2
NM_007110.5 NP_009041.2 telomerase protein component 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
15169895 GOA
enables p53 binding IPI
IPI: Inferred from physical interaction
10597287 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
contributes to telomerase activity IDA
IDA: Inferred from direct assay
12135483 GOA
Biological Process GO Annotation Evidence References Source
involved in telomere maintenance via recombination IDA
IDA: Inferred from direct assay
10810353 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7876352 GOA
located in nuclear matrix IDA
IDA: Inferred from direct assay
7876352 GOA
part of telomerase holoenzyme complex IDA
IDA: Inferred from direct assay
12135483 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEP1 Protein Structure

TEP1_N

TEP1_N: TEP1 N-terminal domain (1 - 30)

TEP1_N

TEP1_N: TEP1 N-terminal domain (31 - 60)

TEP1_N

TEP1_N: TEP1 N-terminal domain (61 - 90)

TEP1_N

TEP1_N: TEP1 N-terminal domain (91 - 119)

TROVE

TROVE: TROVE domain (223 - 676)

DUF4062

DUF4062: Domain of unknown function (DUF4062) (901 - 981)

NACHT

NACHT: NACHT domain (1162 - 1335)

WD40

WD40: WD domain, G-beta repeat (1754 - 1787)

WD40

WD40: WD domain, G-beta repeat (1802 - 1826)

WD40

WD40: WD domain, G-beta repeat (1877 - 1912)

WD40

WD40: WD domain, G-beta repeat (2053 - 2089)

WD40

WD40: WD domain, G-beta repeat (2105 - 2134)

WD40

WD40: WD domain, G-beta repeat (2140 - 2174)

WD40

WD40: WD domain, G-beta repeat (2230 - 2265)

WD40

WD40: WD domain, G-beta repeat (2553 - 2581)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2627 a.a.
Protein Preferred Names Protein Names

telomerase protein component 1

  • TROVE domain family, member 1

TEP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TEP1 Q99973 UBAP2 Homo sapiens Q5T6F2
Y2H Array
32296183
Intra
TEP1 Q99973 UBAP2 Homo sapiens Q5T6F2
Y2H Prey Pooling
32296183
Intra
TEP1 Q99973 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Campylobacteriosis

  • Campylobacter Infections

  • Campylobacter Infection

  • Enteric Campylobacteriosis
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11364 Pten Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11363 PTEN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11365 Pten Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14369 TEP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TEP1 VGNC VGNC:35745
Rattus norvegicus TEP1 RGD RGD:3869
Felis catus TEP1 VGNC VGNC:66079
Macaca mulatta TEP1 VGNC VGNC:78310
Canis familiaris TEP1 VGNC VGNC:47249
Mus musculus TEP1 MGD MGI:109573
Others TEP1 NCBI