Mpc2 - mitochondrial pyruvate carrier 2 Gene

Also Known as Brp44; ESTM43; 0610006C01Rik; 2010002I07Rik; 2610205H19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70456

Summary

Contributes to pyruvate transmembrane transporter activity. Acts upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate; mitochondrial pyruvate transmembrane transport; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Is expressed in early conceptus and embryo. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Apr 2022]

Mpc2 Products (1)

mRNA Protein Name
NM_027430.3 NP_081706.1 mitochondrial pyruvate carrier 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pyruvate transmembrane transporter activity IDA
IDA: Inferred from direct assay
22628554 MGI
contributes to pyruvate transmembrane transporter activity IGI
IGI: Inferred from genetic interaction
22628554 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
22628558 MGI
involved in acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
22628558 MGI
acts upstream of or within mitochondrial pyruvate transmembrane transport IGI
IGI: Inferred from genetic interaction
22628554 MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
24910426 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
22628554 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14651853 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial pyruvate carrier 2

  • brain protein 44

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08607 MPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19353 Mpc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20702 Cbx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25844 Mpc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpc2 NCBI NCBI:25874