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THRSP - thyroid hormone responsive Gene

Also Known as S14; Lpgp; THRP; LPGP1; SPOT14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7069

About THRSP

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:78,063,861-78,068,351 (from NCBI)

This gene has 1 transcript (splice variant), 179 orthologues and 1 paralogue. Biased expression in fat (RPKM 186.6) and liver (RPKM 77.1).

Summary

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

THRSP Products (1)

mRNA	Protein	Name
NM_003251.4	NP_003242.1	thyroid hormone-inducible hepatic protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THRSP Protein Structure

Spot_14

0
100
146 a.a.

Protein Preferred Names	Protein Names
thyroid hormone-inducible hepatic protein	SPOT14 homolog

THRSP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THRSP	Q92748	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	THRSP	Q92748	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	THRSP	Q92748	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	THRSP	Q92748	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	THRSP	Q92748	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	THRSP	Q92748	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	THRSP	Q92748	TUM1	Saccharomyces cerevisiae	Q08686	Y2H Pooling	27107014
Intra	THRSP	Q92748	THRSP	Homo sapiens	Q92748	Y2H Prey Pooling	32296183
Intra	THRSP	Q92748	THRSP	Homo sapiens	Q92748	Y2H Array	25416956
Intra	THRSP	Q92748	THRSP	Homo sapiens	Q92748	Y2H Array	32296183
Intra	THRSP	Q92748	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	THRSP	Q92748	TUM1	Saccharomyces cerevisiae	Q08686	Validated Y2H	27107014
Intra	THRSP	Q92748	THRSP	Homo sapiens	Q92748	Validated Y2H	32296183
Intra	THRSP	Q92748	TUM1	Saccharomyces cerevisiae	Q08686	Y2H Array	27107014
Intra	THRSP	Q92748	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-172661	Kylo-0603		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14502	THRSP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	THRSP	VGNC	VGNC:47356
Macaca mulatta	THRSP	VGNC	VGNC:78351
Mus musculus	THRSP	MGD	MGI:109126
Bos taurus	THRSP	VGNC	VGNC:35848
Felis catus	THRSP	VGNC	VGNC:81929
Rattus norvegicus	THRSP	RGD	RGD:3859
Others	THRSP	NCBI