CXCR4 - C-X-C motif chemokine receptor 4 Gene

Species: Macaca mulatta

Gene Type: protein coding
Gene ID: 707329

About CXCR4

Primary_assembly 12: 21,290,540-21,294,377 reverse strand.Mmul_10:CM014347.1

This gene has 3 transcripts (splice variants), 285 orthologues and 24 paralogues.

CXCR4 Products (1)

mRNA Protein Name
NM_001042645.1 NP_001036110.1 C-X-C chemokine receptor type 4

CXCR4 Protein Structure

CXCR4_N

CXCR4_N: pfam12109 (5 - 37)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (38 - 312)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (38 - 65)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (72 - 97)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (108 - 138)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (150 - 172)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (195 - 224)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (231 - 261)

7tmA_CXCR4

7tmA_CXCR4: cd15179 (280 - 305)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 4

  • CXC-R4

  • CXCR-4

  • LESTR

  • SDF-1 receptor

  • chemokine (C-X-C motif) receptor 4

  • fusin

  • leukocyte-derived seven transmembrane domain receptor

  • stromal cell-derived factor 1 receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10046 Plerixafor Antagonist 99.90% Yes
HY-50912 Plerixafor octahydrochloride Antagonist 99.09% Yes
HY-P0171 Motixafortide Antagonist 99.76% Unkown
HY-50101A Mavorixafor trihydrochloride Antagonist 99.75% Yes
HY-50101 Mavorixafor Antagonist 99.72% Yes
HY-50101C Mavorixafor hydrochloride Antagonist 99.64% Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-P1682A Balixafortide TFA Antagonist 99.89% Phase 3
HY-P1682 Balixafortide Antagonist 98.20% Phase 3
HY-12488 LY2510924 Inhibitor 99.85% Phase 2
HY-19867A Burixafor hydrobromide Antagonist 99.70% Phase 2
HY-P1103 CTCE-9908 Antagonist 99.54% Phase 2
HY-114244 USL311 Antagonist 99.97% Phase 2
HY-19867 Burixafor Antagonist / Phase 2
HY-13696 MSX-122 Antagonist 98.16% Phase 1
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99272 Ulocuplumab Antagonist 99.90% Phase 3
HY-P991656 LY-2624587 Antagonist / Phase 1
HY-P991647 ALX-0651 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (57)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0011 Baohuoside I Inhibitor 99.94% Unkown
HY-W087028 NOTA-NHS ester ≥97.0% Unkown
HY-101458A IT1t dihydrochloride Antagonist 99.77% Unkown
HY-111793A NUCC-390 dihydrochloride Agonist 98.19% Unkown
HY-P3612 CTCE-0214 Agonist 99.96% Unkown
HY-P1104A FC131 TFA Antagonist 99.87% Unkown
HY-15478 WZ811 Antagonist 99.80% Unkown
HY-P1102 TC14012 Modulator 99.77% Unkown
HY-D0976 NF279 Antagonist 98.5% Unkown
HY-111793 NUCC-390 Agonist 98.01% Unkown
HY-P10415 EPI-X4 Antagonist 98.91% Unkown
HY-15971A AMD 3465 Antagonist 98.24% Unkown
HY-15971 AMD 3465 hexahydrobromide Antagonist 98.0% Unkown
HY-P7061A ALX 40-4C Trifluoroacetate Inhibitor 99.78% Unkown
HY-122058A KRH-3955 hydrochloride Antagonist / Unkown
HY-161735 CXCR4-IN-3 Inhibitor 99.69% Unkown
HY-167851 CCX662 Inhibitor 98.62% Unkown
HY-P0172 ATI-2341 Agonist 99.64% Unkown
HY-146413 HF50731 Antagonist 99.66% Unkown
HY-147978 CXCR4 antagonist 8 Antagonist 99.88% Unkown
HY-146372 CXCR4 antagonist 5 Antagonist / Unkown
HY-P4111A Peptide R TFA Antagonist 98.34% Unkown
HY-P7061 ALX 40-4C Inhibitor / Unkown
HY-P10971 Nef-M1 Antagonist 98.87% Unkown
HY-146054 CXCR4 modulator-2 Modulator / Unkown
HY-P10973 Peptide R analogue 10 Antagonist 99.47% Unkown
HY-P4111 Peptide R Antagonist / Unkown
HY-103010 MSX-130 Antagonist 98.00% Unkown
HY-168095 CXCR4 antagonist 10 Inhibitor 99.27% Unkown
HY-P1104 FC131 Antagonist / Unkown
HY-101458 IT1t Antagonist / Unkown
HY-147979 CXCR4 antagonist 9 Antagonist / Unkown
HY-P11011A Peptide R54 acetate Antagonist 99.88% Unkown
HY-162632 Hit 14 Inhibitor ≥99.0% Unkown
HY-103009 MSX-127 Antagonist 99.68% Unkown
HY-183994 HL82624 Agonist / Unkown
HY-146401 CXCR4 antagonist 6 Antagonist / Unkown
HY-148640 WK500B Activator / Unkown
HY-144286 CXCR4 antagonist 3 Inhibitor / Unkown
HY-P11019 IS4 Antagonist / Unkown
HY-178205 BPRCX807 Antagonist / Unkown
HY-129094 ICT5040 Antagonist / Unkown
HY-P11451 Pentixather / Unkown
HY-146053 CXCR4 modulator-1 Modulator / Unkown
HY-P1102A TC14012 TFA Modulator / Unkown
HY-P1103A CTCE-9908 TFA Antagonist / Unkown
HY-P11011 Peptide R54 Antagonist / Unkown
HY-P10427 DV1 Antagonist / Unkown
HY-136437 CXCR4 antagonist 1 Antagonist / Unkown
HY-182850 UCUF-965 Modulator / Unkown
HY-P10429 RCP168 Antagonist / Unkown
HY-N9858 Herpetin Activator / Unkown
HY-177799 BPRCX 714 Antagonist / Unkown
HY-147808 CXCR4 antagonist 7 Antagonist / Unkown
HY-115493 TIQ-15 Antagonist / Unkown
HY-144285 CXCR4 antagonist 4 Antagonist / Unkown
HY-123819 KRH-1636 Antagonist / Unkown
Bioactive MoleculesInhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991568 AT009 Modulator / Unkown
HY-P991744 Anti-Mouse CXCR4 Antibody (Cx4Mab-1) / Unkown
HY-P992439 PF-06747143 Inhibitor / Unkown
HY-P992405 MEDI-3185 Antagonist / Unkown
HY-P992397 KY1051 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CXCR4 NCBI NCBI:7852