CLEC3B - C-type lectin domain family 3 member B Gene

Also Known as TN; TNA; MCDR4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7123

About CLEC3B

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,026,303-45,036,071 (from NCBI)

This gene has 3 transcripts (splice variants), 251 orthologues and 2 paralogues. Broad expression in spleen (RPKM 63.9), fat (RPKM 63.1) and 20 other tissues.

Summary

Enables calcium ion binding activity; heparin binding activity; and kringle domain binding activity. Involved in bone mineralization and cellular response to transforming growth factor beta stimulus. Located in cytoplasm; extracellular space; and granular component. Part of collagen-containing extracellular matrix. Implicated in osteoarthritis. [provided by Alliance of Genome Resources, Apr 2022]

CLEC3B Products (2)

mRNA Protein Name
NM_001308394.2 NP_001295323.1 tetranectin isoform 2
NM_003278.3 NP_003269.2 tetranectin isoform 1precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
9786936 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
10727405 GOA
enables kringle domain binding IPI
IPI: Inferred from physical interaction
9786936 GOA
Biological Process GO Annotation Evidence References Source
involved in bone mineralization IDA
IDA: Inferred from direct assay
7798325 GOA
involved in ossification IEP
IEP: Inferred from expression pattern
7798325 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
7798325 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
7798325 GOA
located in granular component IDA
IDA: Inferred from direct assay
15848710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC3B Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (88 - 198)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

tetranectin

  • plasminogen kringle 4-binding protein

Recombinant CLEC3B Proteins

Cat. No. Product Name Accession Purity
HY-P7815 Tetranectin/CLEC3B Protein, Human (HEK293, His) AAH11024.1 (E22-V202) ≥ 95%, as determined by reducing SDS-PAGE.

CLEC3B Antibodies

Cat. No. Product Name Application Reactivity
HY-P82150 Tetranectin Antibody (YA1895) IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Macular Dystrophy, Retinal, 4

  • MCDR4
Ureteric Orifice Cancer

  • Malignant Neoplasm Of Ureteric Orifice Of Urinary Bladder

  • Malignant Tumor Of Ureteric Orifice

  • Orifice Of The Ureter
Osteoarthritis

  • Osteoarthrosis

  • Degenerative Joint Disease

  • Hypertrophic Arthritis

  • Arthropathy

  • Degenerative Polyarthritis

  • Degenerative Arthritis

  • Osteoarthrosis And Allied Disorder

  • Arthritis, Degenerative

  • Oa

  • Osteoarthritis Deformans

  • Osteoarthrosis Deformans

  • Kashin-Beck Disease
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Pelvic Inflammatory Disease

  • Pid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02790 CLEC3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18702 Clec3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25189 Clec3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLEC3B VGNC VGNC:54591
Macaca mulatta CLEC3B VGNC VGNC:110373
Bos taurus CLEC3B VGNC VGNC:27429
Felis catus CLEC3B VGNC VGNC:60950
Rattus norvegicus CLEC3B RGD RGD:1311031
Mus musculus CLEC3B MGD MGI:104540
Others CLEC3B NCBI